Ras GTPase-activating protein-binding protein 1 is an enzyme that in humans is encoded by the G3BP1 gene. [5][6][7] This gene encodes one of the DNA-unwinding enzymes which prefers partially unwound 3'-tailed substrates and can also unwind partial RNA/DNA and RNA/RNA duplexes in an ATP-dependent fashion.

2024年12月25日 · G3BP1 (G3BP Stress Granule Assembly Factor 1) is a Protein Coding gene. Diseases associated with G3BP1 include Glioma Susceptibility 1 and Chikungunya. Among its related pathways are SARS-CoV-2 Infection and Infectious disease. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and mRNA binding.

Ras-GTPase-activating protein (GAP)-binding protein 1 (G3BP1) is a multi-functional protein that is best known for its role in the assembly and dynamics of stress granules. Recent studies have highlighted that G3BP1 also has other functions related to RNA metabolism.

2020年4月16日 · Here, we show that SGs assemble through liquid-liquid phase separation (LLPS) arising from interactions distributed unevenly across a core protein-RNA interaction network. The central node of this network is G3BP1, which functions as a molecular switch that triggers RNA-dependent LLPS in response to a rise in intracellular free RNA concentrations.

Ras‐GTPase‐activating protein (GAP)‐binding protein 1 (G3BP1) is a multi‐functional protein that is best known for its role in the assembly and dynamics of stress granules. Recent studies have highlighted that G3BP1 also has other functions related to RNA metabolism.

2021年8月29日 · Ras-GTPase-activating protein (SH3 domain)-binding protein (G3BP) is an RNA binding protein. G3BP is a key component of stress granules (SGs) and can interact with many host proteins to regulate the expression of SGs. As an antiviral factor, G3BP can interact with viral proteins to regulate the assembly of SGs and thus exert antiviral effects.

2020年4月16日 · The central node of this network is G3BP1, which functions as a molecular switch that triggers RNA-dependent LLPS in response to a rise in intracellular free RNA concentrations.

2025年2月9日 · G3BP1 promotes human breast cancer cell proliferation through coordinating with GSK-3beta and stabilizing beta-catenin. G3BP1 binds to guanine quadruplexes in mRNAs to modulate their stabilities. G3BP1 inhibits Cul3 (SPOP) to amplify AR signaling and promote prostate cancer.

2025年2月6日 · Here, we show that the RNA-binding protein G3BP1 preferentially interacts with unfolded RNA, driving the assembly of RNP granule-like condensates that establish RNA-RNA interactions. These RNA-RNA interactions limit the mobility and translatability of sequestered mRNAs and stabilize the condensates.

Following granule formation, G3BP1 is dispensable for the RNA component of granules to persist in vitro and in cells when RNA decondensers are inactivated. These results demonstrate that G3BP1 functions as an “RNA condenser,” a protein that promotes intermolecular RNA-RNA interactions stabilizing RNA condensates, leading to RNP granule persistence.

This review summarizes the biology of G3BP including their structure, function, localization, role in cancer progression, virus replication, mRNA stability, and SG formation. We will also discuss the potential of G3BPs as a therapeutic target.

2024年8月27日 · In this study, we investigated the crucial features of G3BP in mediating SG formation in human cells by analyzing its orthologs from different species.

2018年12月3日 · G3BP1 enhanced DNA binding of cGAS by promoting the formation of large cGAS complexes. G3BP1 deficiency led to inefficient DNA binding by cGAS and inhibited cGAS-dependent interferon (IFN)...

2021年8月30日 · Ras-GTPase-activating protein (SH3 domain)-binding protein (G3BP) is an RNA binding protein. G3BP is a key component of stress granules (SGs) and can interact with many host proteins to regulate the expression of SGs.

2025年2月27日 · Activation of the mTOR pathway, which increases overall cap-dependent protein synthesis, has been shown to promote axon regeneration in the injured CNS and PNS (3–9).Indeed, deletion or inhibition of PTEN that increases activity of the mTOR pathway promotes regeneration of corticospinal tract axons in the injured spinal cord that are typically …

G3BP1 and 2 are the nodes of highest centrality within this network and by virtue of this position are essential for SG assembly under certain conditions. Biophysical studies revealed details of how G3BP1 functions as a molecular switch that triggers RNA-dependent LLPS.

2024年12月26日 · Here, we show that the RNA-binding protein G3BP1 preferentially interacts with unfolded RNA, driving the assembly of RNP granule-like condensates that establish RNA-RNA interactions. These RNA-RNA interactions limit the mobility and translatability of sequestered mRNAs and stabilize the condensates.

2024年10月25日 · Stress granules (SGs) are macromolecular assemblies that form under cellular stress. Formation of these membraneless organelles is driven by the condensation of RNA and RNA-binding proteins such as G3BPs. G3BPs form …

Ras-GTPase-activating protein (GAP)-binding protein 1 (G3BP1) is a multi-functional protein that is best known for its role in the assembly and dynamics of stress granules. Recent studies have highlighted that G3BP1 also has other functions related to RNA metabolism.

This review summarizes the biology of G3BP including their structure, function, localization, role in cancer progression, virus replication, mRNA stability, and SG formation. We will also discuss the potential of G3BPs as a therapeutic target.