2024年12月25日 · FZD2 (Frizzled Class Receptor 2) is a Protein Coding gene. Diseases associated with FZD2 include Omodysplasia 2 and Robinow Syndrome, Autosomal Dominant 1. Among its related pathways are ncRNAs involved in Wnt signaling in hepatocellular carcinoma and Autodegradation of the E3 ubiquitin ligase COP1.

2024年4月17日 · FZD2. An early study found that FZD2 is elevated in various metastatic cancer cell lines and is strongly associated with EMT, which is a hallmark of cancer metastasis.

Frizzled-2 (Fz-2) is a protein that in humans is encoded by the FZD2 gene. [5] [6] [7] Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins.

2014年11月6日 · Pharmacologic and genetic perturbations reveal that Fzd2 drives EMT and cell migration through a previously unrecognized, noncanonical pathway that includes Fyn and Stat3. A gene signature regulated by this pathway predicts metastasis and overall survival in patients.

The inhibitory effect of Wnt5a is mediated by Fzd2. Wnt5a–Fzd2 suppresses β-catenin–TCF activity in HCC cells, suggesting that this signaling may hinder tumor initiation and growth. However, as described above, Wnt5a–Fzd2 also functions as a prometastatic signaling, especially in the absence of β-catenin pathway activity. Fzd3/6 Subfamily

The FZD2 gene provides instructions for making a protein that plays a critical role in development before birth. Learn about this gene and related health conditions.

2025年1月4日 · Clinical resource with information about FZD2, Autosomal dominant omodysplasia, and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, PharmGKB and clinicaltrials.gov.

Integrated weighted gene coexpression network analysis identifies Frizzled 2 (FZD2) as a key gene in invasive malignant pleomorphic adenoma. FZD2 acts as an oncogene in tongue cancer, promoting cell growth, invasion and migration. Fz2 and Wnt5a, might be involved in human Amyotrophic lateral sclerosis pathology.

2025年1月4日 · Title: Integrated weighted gene coexpression network analysis identifies Frizzled 2 (FZD2) as a key gene in invasive malignant pleomorphic adenoma. FZD2 acts as an oncogene in tongue cancer, promoting cell growth, invasion and migration.

2023年2月1日 · Frizzled 2 (FZD2) is a transmembrane Wnt receptor. We previously identified a pathogenic human FZD2 variant in individuals with FZD2-associated autosomal dominant Robinow syndrome. The variant encoded a protein with a premature stop and loss of 17 amino acids, including a region of the consensus dis …