2024年12月25日 · Complete information for FSCN1 gene (Protein Coding), Fascin Actin-Bundling Protein 1, including: function, proteins, disorders, pathways, orthologs, and expression.

Fascin is a protein that in humans is encoded by the FSCN1 gene. [5][6][7] FSCN1 has been shown to interact with Low affinity nerve growth factor receptor [8] and PKC alpha. [9] ^ …

Fascin actin-bundling protein 1 (FSCN1) is an actin-bundling protein that is capable of inducing membrane protrusions and plays critical roles in cell migration, motility, adhesion, and other cellular interactions.

2016年8月22日 · Fscn1 specifically interacts with TGF-β family type I receptors, and its depletion disrupts the association between receptors and actin filaments and sequesters the internalized receptors into...

CircFSCN1 induces tumor progression and triggers epithelial-mesenchymal transition in bladder cancer through augmentation of MDM2-mediated p53 silencing. Fascin-1 expression is associated with neuroendocrine prostate cancer and directly suppressed by androgen receptor.

2023年7月1日 · The actin-bundling protein fascin (FSCN1) is overexpressed in aggressive ACC and represents a reliable prognostic indicator. FSCN1 has been shown to synergize with VAV2, a guanine nucleotide exchange factor for the Rho/Rac GTPase family, to enhance the invasion properties of ACC cancer cells.

2021年1月20日 · The overexpression of FSCN1 in cancer cells has been associated with tumor growth, migration, invasion, and metastasis. Currently, FSCN1 is recognized as a candidate biomarker for multiple cancer types and as a potential therapeutic target.

2007年1月23日 · Organizes filamentous actin into parallel bundles (PubMed: 20393565, PubMed: 21685497, PubMed: 23184945). Plays a role in the organization of actin filament bundles and …

2024年2月4日 · Title: FSCN1 promotes proliferation, invasion and glycolysis via the IRF4/AKT signaling pathway in oral squamous cell carcinoma. Downregulation of fascin induces collective cell migration in triple-negative breast cancer.

2024年3月1日 · Fascin proteins organize F-actin into parallel bundles, and are required for the formation of actin-based cellular protrusions. The encoded protein plays a critical role in cell migration, motility, adhesion and cellular interactions.