2024年12月25日 · FRS2 (Fibroblast Growth Factor Receptor Substrate 2) is a Protein Coding gene. Diseases associated with FRS2 include Hematologic Cancer and Glioma Susceptibility 1. Among its related pathways are Downstream signaling of activated FGFR2 and Insulin receptor signalling cascade.

2009年8月4日 · These results suggest that PS/T of FRS2 mediated by the FRS2-MAPK negative regulatory loop may function as a molecular switch integrating negative regulatory signals from other pathways into...

fgf细胞内信号通路主要有四种，即frs2-ras-map激酶途径、pi3激酶- akt通路、plcγ通路以及stat通路。 当配体与受体结合后，受体形成二聚体，胞内的酪氨酸激酶被激活，受体上多个酪氨酸残基被磷酸化。

FRS2 is an 80 kDa membrane-anchored signal transducing adaptor protein (STAP) that links specific activated Receptor Tyrosine Kinases (RTKs) to multiple downstream signaling pathways, most notably the MAPK/ERK, PI3K/AKT/mTOR and PLCγ pathways. [8] It is overexpressed and amplified in several cancer types, including prostate cancer. [9] [10]

成纤维生长因子(FGF)信号通路在多种生命活动中发挥着重要作用.FRS2(Fibroblast growth factor Receptor Substrate2)即人的成纤维生长因子受体底物2,属于接头蛋白(adapter protein),是FGF信号通路的主要信号传导分子.FRS2可以在被FGFR磷酸化后,直接或间接的与Grb2蛋白结合,通 …

关于 frs2 Cytogenetic location: 12q15 Genomic coordinates (GRCh38): 12:69,470,388-69,579,793 (from NCBI) This gene has 11 transcripts (splice variants), 230 orthologues and 7 paralogues.

2025年2月9日 · Results identify FRS2 as an oncogene in a subset of high-grade serous ovarian cancers that harbor FRS2 amplifications. Increased expression of FRS2alpha (and FGFR1) was associated with decreased progression-free survival among patients with metastatic renal cell carcinoma treated with sorafenib.

这些实验建立了FRS2 alpha在通过FGFR进行信号传导中的核心作用，并证明FRS2 alpha介导了多种对胚胎发育至关重要的FGFR依赖性信号通路。 "点击查看英文标题和摘要"

2013年2月15日 · Fibroblast growth factor (FGF) receptor (FGFR) substrate 2 (FRS2) is an adaptor protein that plays a critical role in FGFR signaling. FRS2 is located on chromosome 12q13-15 that is frequently amplified in liposarcomas. The significance of FRS2 and FGFR signaling in high-grade liposarcomas is unknown …

Ong SH, Guy GR, Hadari YR, Laks S, Gotoh N, Schlessinger J, Lax I. FRS2 proteins recruit intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor receptors.