Fos-related antigen 1 (FRA1) is a protein that in humans is encoded by the FOSL1 gene. [5][6] The Fos gene family consists of 4 members: c-Fos, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1.

Fos-related antigen-1 (FRA-1) is a member of activator protein-1 (AP-1) transcription factor superfamily, and FRA-1 is highly expressed in colon cancer, breast cancer, gastric cancer, lung cancer, bladder cancer, and other tumors. The expression level of …

Jun 1, 2022 · FRA-1 plays a key role in regulating inflammatory reaction, and interleukin signal transduction related gene expression. FRA-1 can promote the proliferation or apoptosis of cancer cells by regulating PI3K/AKT and other signaling pathways. Some drugs, non-coding RNA and other small molecules can regulate the expression and function of FRA-1.

May 8, 2020 · Among the FOS -related members of the AP-1 dimeric complex, the transcription factor Fra-1, encoded by FOSL1, is crucially involved in human tumor progression and metastasis, thus representing...

Aug 10, 2022 · Fra-1 (Fos-related antigen1), a member of transcription factor activator protein (AP-1), plays an important role in cell proliferation, apoptosis, differentiation, inflammation, oncogenesis and tumor metastasis. Accumulating evidence suggest that the malignancy and invasive ability of tumors can be significantly changed by directly targeting Fra-1.

May 5, 2023 · Among FOS-related components of the dimeric AP-1 transcription factor, the oncoprotein FRA-1 (encoded by FOSL1 ) is a key regulator of invasion and metastasis. The well-established FRA-1 pro-invasive activity in breast cancer, in which FOSL1 is overexpressed in the TNBC (Triple Negative …

Mar 14, 2022 · Among components of the AP-1 complex, the FOS-family transcription factor Fra-1, encoded by FOSL1, has emerged as a prominent therapeutic target. Fra-1 is overexpressed in most solid tumors, in response to the BRAF-MAPK, Wnt-beta-catenin, Hippo-YAP, IL-6-Stat3, and other major oncogenic pathways.

FRA-1的表达水平与肿瘤细胞增殖、凋亡、转化、迁移和侵袭等过程密切相关，是许多肿瘤潜在的治疗靶点和预后因素。 阐明FRA-1的详细作用机制可为肿瘤的诊断、治疗和预后提供理论依据，对研究肿瘤的病因和发病机制具有重要意义。 本文总结了FRA-1在各种肿瘤组织和细胞中的表达水平及影响因素，以及FRA-1表达水平对肿瘤细胞生物学行为和信号转导机制的影响。 同时阐述了FRA-1在炎症中的信号转导机制。 此外，对影响FRA-1表达和功能的相关代谢物、药物和非编 …

摘要 在激活蛋白1 (activator protein 1,AP-1)二聚体复合物转录因子家族的FOS亚家族成员中,由FOSL1基因编码的转录因子Fra-1对人类肿瘤的转移和进展起到至关重要的作用。 Fra-1在大多数肿瘤中表达... 展开更多 在激活蛋白1 (activator protein 1,AP-1)二聚体复合物转录因子家族的FOS亚家族成员中,由FOSL1基因编码的转录因子Fra-1对人类肿瘤的转移和进展起到至关重要的作用。 Fra-1在大多数肿瘤中表达上调,且被不同的信号通路激活。

Nov 10, 2014 · In this review, we examine a growing body of work implicating the transcription factor FOS-related antigen 1 (FRA-1) as a central node in tumour cell plasticity networks, and discuss mechanisms...