Both naive and memory FOXP3 T-cells are required for effective maintenance of tolerance and prevention of autoimmune diseases throughout the body. Many factors such as cytokines and noncytokine factors regulate the generation of FOXP3 T-cells.

2017年7月31日 · This Review considers how forkhead box protein P3 (FOXP3) — the key transcription factor of regulatory T (Treg) cells — is regulated both at the transcriptional level and through post ...

2024年12月25日 · FOXP3 (Forkhead Box P3) is a Protein Coding gene. Diseases associated with FOXP3 include Immunodysregulation, Polyendocrinopathy, And Enteropathy, X-Linked and Hydrops Fetalis. Among its related pathways are Gene expression (Transcription) and Inflammatory bowel disease signaling.

The FOXP3 gene provides instructions for producing the forkhead box P3 (FOXP3) protein. The FOXP3 protein attaches (binds) to specific regions of DNA and helps control the activity of genes that are involved in regulating the immune system.

FOXP3 is known to both activate and repress target genes by epigenetically regulating histone modifications of target promoters. In this review, we first focus on germline mutations found in the FOXP3 gene among IPEX patients, then outline possible molecular mechanisms by which FOXP3 epigenetically regulates its targets. Finally, we discuss ...

2023年11月29日 · FOXP3 uses the forkhead domain to form a higher-order multimer after binding to TnG repeat microsatellites.

2015年2月16日 · FOXP3+ regulatory T (Treg) cells are critical in maintaining immune tolerance and homeostasis of the immune system.

Schematic representation of the Foxp3 protein and the location of the epitopes reactive with antibodies. Foxp3 contains a Zn finger/Leucine zipper and a conserved Forkhead Domain. In addition, in human Tregs, Exon 2 may be alternatively spliced (black box).

FOXP3+ Tregs mediated immune evasion in tumor environment. FOXP3+ regulatory T cells regulate immune responses by producing inhibitory cytokines, such as TGF-β, IL-4, IL-10 and IL-35, inhibiting T effector cells (Teff), Antigen-Presenting Cells (APCs) and Natural Killer (NK) cells.

2020年11月17日 · Regulatory T (Treg) cell identity is defined by the lineage-specifying transcription factor (TF) Foxp3. van der Veeken et al. leverage naturally occurring genetic variation in wild-derived inbred mice and reveal that Foxp3 works in a largely indirect manner by fine-tuning the activity of other transcription factors, including TCF1.