Forkhead box protein O1 (FOXO1), also known as forkhead in rhabdomyosarcoma (FKHR), is a protein that in humans is encoded by the FOXO1 gene. [5] FOXO1 is a transcription factor that plays important roles in regulation of gluconeogenesis and glycogenolysis by insulin signaling , and is also central to the decision for a pre adipocyte to commit ...

2024年12月25日 · FOXO1 (Forkhead Box O1) is a Protein Coding gene. Diseases associated with FOXO1 include Rhabdomyosarcoma 2 and Diffuse Large B-Cell Lymphoma. Among its related pathways are IL-9 Signaling Pathways and FOXO-mediated transcription.

2002年6月7日 · We now report on the role of forkhead homologue in rhabdomyosarcoma (FKHR), a recently described member of the forkhead/winged-helix transcription factor family, as a mediator of endometrial differentiation.

In this study, we examined expressions of both nonphosphorylated (FKHR) and phosphorylated forms (p-FKHR) of FKHR in a large cohort of radical prostatectomies using tissue microarray (TMA) technology.

The forkhead transcription factor Foxo1 (previously known as Fkhr) is phosphorylated in an insulin-responsive manner by PIP 3-dependent kinases, such as Akt and Sgk (39–50). Phosphorylation leads to nuclear exclusion and inhibition of Foxo1-dependent transcription (39–42, 44–55).

2003年9月17日 · It has been shown that FKHR is phosphorylated via insulin or growth factor signaling cascades, resulting in its cytoplasmic retention and the repression of target gene expression. Here, we investigate the fate of FKHR after cells are stimulated by insulin.

FOXO transcription factors regulate cellular homeostasis, longevity and response to stress. FOXO1 (also known as FKHR) is a key regulator of hepatic glucose production and lipid metabolism, and its specific inhibition may have beneficial effects on ...

1999年12月8日 · Recently, two mammalian highly related forkhead transcription factors FKHRL1 and AFX and their nematode homologue Daf-16 have been found to be targets of this kinase. Here we show that Akt, but not...

While performing a large-scale analysis of mRNA transcripts in the murine thymus, our attention was drawn to the forkhead family transcription factor FKHR. Here we demonstrate that FKHR is expressed in thymocytes, most prominently in those that are undergoing positive selection.

2002年6月7日 · The mammalian DAF-16-like transcription factors, FKHR, FKHRL1, and AFX, function as key regulators of insulin signaling, cell cycle progression, and apoptosis downstream of phosphoinositide 3-kinase. Gene activation through binding to insulin response sequences (IRS) has been thought to be essential for mediating these functions.