Mitochondrial fission protein 1 (Fis1) was identified in yeast as being essential for mitochondrial division or fission and subsequently determined to mediate human mitochondrial and peroxisomal fission.

2024年12月25日 · FIS1 (Fission, Mitochondrial 1) is a Protein Coding gene. Diseases associated with FIS1 include Spinocerebellar Ataxia 12 and Cranial Nerve Disease. Among its related pathways are Peroxisomal lipid metabolism and CAMKK2 pathway. Gene Ontology (GO) annotations related to this gene include signaling receptor binding.

2022年4月27日 · FIS1 is a Type II integral membrane protein anchored to the mitochondrial outer membrane exposing an N-terminal domain comprised of two tetratricopeptide repeats (TPRs) to the cytoplasm (15–17, 25–27).

2021年12月1日 · Fis1 pY38 promoted mitochondrial fission by recruiting the mitochondrial fission GTPase dynamin-related protein-1 (Drp1) to mitochondria. Fragmented mitochondria fueled actin filament...

2021年3月25日 · Mitochondrial fission protein 1 (Fis1) was identified in yeast as being essential for mitochondrial division or fission and subsequently determined to mediate human mitochondrial and peroxisomal fission.

Fis1, a protein on the mitochondrial outer membrane, is thought to mediate mitochondrial fission. However, Fis1 null worms and mammalian cells only display mild fission defects but show aberrant mitophagy. To assess Fis1 function in vivo, we generated conditional knock-out Fis1 mice to allow for specific Fis1 deletion in adult skeletal muscle ...

Here, we show that hFis1‐mediated mitochondrial fragmentation occurs in the absence of Drp1 and Dyn2, suggesting that they are dispensable for hFis1 function. hFis1 instead binds to Mfn1, Mfn2, and OPA1 and inhibits their GTPase activity, thus blocking the fusion machinery.

Fis1, a protein on the mitochondrial outer membrane, is thought to mediate mitochondrial fission. However, Fis1 null worms and mammalian cells only display mild fission defects but show aberrant mitophagy.

2025年2月16日 · Our findings demonstrate that FIS1 upregulation, induced by lipotoxicity, exacerbates mitochondrial fragmentation through its interaction with DRP1, which leads to a significant increase in mitochondrial ROS (mitoROS) production, which in turn triggers NLRP3-dependent pyroptosis.

Enables identical protein binding activity. Involved in several processes, including cellular response to thapsigargin; mitochondrial fragmentation involved in apoptotic process; and positive regulation of mitochondrial fission. Located in mitochondrion and peroxisomal membrane. Is integral component of mitochondrial outer membrane.