2023年7月31日 · A retrospective electronic medical record review from the United States found that osteoarthritis, a common comorbidity of atrial fibrillation, significantly increased the incidence of atrial fibrillation.

Fibrillation, erosion and cracking initially appear in the superficial layer of cartilage and progress over time to deeper layers, resulting eventually in large clinically observable erosions.

2023年2月20日 · Usually, the earliest changes that occur in osteoarthritis are at the level of the articular cartilage, which develops surface fibrillation, irregularity, and focal erosions. These erosions eventually extend down to the bone and continually expand …

The earliest pathological changes in OA are commonly seen on the articular cartilage surface, with fibrillation occurring in focal regions experiencing maximal load. The proliferation of chondrocytes, the only cell type present in cartilage, dramatically accelerates in response to …

Fibrillation of cartilage from OA femoral head is associated with a defective adhesion of chondrocytes to fibronectin. The process is suggested to be dependent of PKC and/or calmodulin-dependent kinases and potentially reversible. Conceivably, it could play a …

Osteoarthritis (OA) is the most common degenerative joint disease and a major cause of pain and disability in adult individuals. The etiology of OA includes joint injury, obesity, aging, and heredity. However, the detailed molecular mechanisms of OA ...

2014年11月7日 · Stage 2 involves the fibrillation and erosion of the cartilage surface, with a subsequent release of proteoglycan and collagen fragments into the synovial fluid. In stage 3, the breakdown...

2004年1月1日 · Osteoarthritis (OA) is characterized by a degeneration of articular cartilage, in which the breakdown leads to matrix fibrillation, fissure appearance, gross ulceration, and full-thickness loss of the joint surface.

2003年7月1日 · Osteoarthritis is a chronic degenerative disorder characterised by cartilage loss. It is extremely prevalent in society and is a major cause of disability. It is important to treat osteoarthritis effectively using a multidisciplinary approach tailored to the patient’s needs.

We suggest that the progression of early cartilage fibrillation to symptomatic OA arises initially as a consequence of the release into synovial fluid of cartilage-derived antigens that activate joint lining macrophages and circulating leukocytes, thereby establishing a synovitis.