Fibroblast growth factor-binding protein 1 is a protein that in humans is encoded by the FGFBP1 gene. [ 5 ] [ 6 ] [ 7 ] FGFBP1, or HBP17, binds to both acidic FGF1 and basic FGF2 fibroblast growth factors in a reversible manner.

2024年12月25日 · FGFBP1 (Fibroblast Growth Factor Binding Protein 1) is a Protein Coding gene. Diseases associated with FGFBP1 include Colorectal Adenocarcinoma and Gallbladder Squamous Cell Carcinoma. Among its related pathways are Signaling by FGFR2 and Nuclear receptors meta-pathway.

Gene ID: 9982, updated on 8-Feb-2025. This gene encodes a secreted fibroblast growth factor carrier protein. The encoded protein plays a critical role in cell proliferation, differentiation and migration by binding to fibroblast growth factors and potentiating their …

FGFBP1 has been shown to play important roles at NMJs during development, normal aging and in ALS. It has also been found to be important for repairing neural circuits in the spinal cord. There is also evidence suggesting roles for both FGFBP1 and FGFBP3 in the formation and function of neural circuits in the brain.

2025年2月8日 · Title: A common variant in fibroblast growth factor binding protein 1 (FGFBP1) is associated with bone mineral density and influences gene expression in vitro.

Fibroblast growth factor-binding protein 1 (FGFBP1) is a secreted chaperone that mobilizes paracrine-acting FGFs, stored in the extracellular matrix, and presents them to their cognate receptors. FGFBP1 enhances FGF signaling including angiogenesis during cancer progression and is upregulated in var …

As a secreted protein, fibroblast growth factor-binding protein 1 (FGFBP1) binds and releases immobilized fibroblast growth factor (FGF) from the extracellular matrix. In addition, FGFBP1 enhances the activities of FGFs by chaperoning them to their receptors .

FGFRL1, with structural similarity to FGFRs, is a membrane protein of ∼500 amino acids with three extracellular immunoglobulin-like domains (I, II, and III), a transmembrane domain (TM), and a short intracellular tail with no tyrosine kinase domain. SP indicates a cleavable secreted signal sequence. Table 2.

2021年7月28日 · Fibroblast growth factor-binding protein 1 (FGFBP1) promotes fibroblast growth factor (FGF) activity by releasing FGFs from extracellular matrix storage.

2020年8月24日 · Fgfbp1 is expressed in the CNS endothelium and secreted into the vascular basement membrane during BBB formation. Endothelial genetic ablation of Fgfbp1 results in transient hypervascularization but delays BBB maturation in specific CNS regions, as evidenced by both upregulation of Plvap and increased tracer leakage across the neurovasculature ...

2018年9月1日 · FGFBP1 has been shown to play important roles at NMJs during development, normal aging and in ALS. It has also been found to be important for repairing neural circuits in the spinal cord. There is also evidence suggesting roles for both FGFBP1 and FGFBP3 in the formation and function of neural circuits in the brain.

2017年11月20日 · A genetic polymorphism in the human FGFBP1 gene was associated with higher gene expression and an increased risk of familial hypertension. Here, we report on the effects of inducible BP1 expression in a transgenic mouse model.

2019年12月1日 · In the present study, we investigated whether FBW7 inhibited cell proliferation and metastasis by decreasing the expression of FGFBP1 in pancreatic cancer. We initially confirmed that pancreatic cancer patients with higher FGFBP1 expression had a worse prognosis.

The paracrine-acting FGFs are stored in the extracellular matrix and their release is controlled by a secreted FGF-binding protein (FGF-BP, FGFBP1, BP1) that modulates FGF receptor (FGFR) signaling. A genetic polymorphism in the human FGFBP1 gene was associated with higher gene expression and an increased risk of familial hypertension.

2018年1月1日 · Fibroblast growth factor-binding protein 1 (FGFBP1) is a secreted chaperone that mobilizes paracrine-acting FGFs, stored in the extracellular matrix, and presents them to their cognate receptors. FGFBP1 enhances FGF signaling including angiogenesis during cancer progression and is upregulated in various cancers.

2011年11月1日 · FGFBP1 (alias BP1, FGF-BP1, or HBp17) expression is required for embryonic survival, can modulate FGF-dependent vascular permeability in embryos, and is an angiogenic switch in human cancers. To determine the function of BP1 in vivo, we generated tetracycline-regulated conditional BP1 transgenic mice. BP1-expressing adult mice are viable ...

Acts as a carrier protein that release fibroblast-binding factors (FGFs) from the extracellular matrix (EM) storage and thus enhance the mitogenic activity of FGFs. Enhances FGF2 signaling during tissue repair, angiogenesis and in tumor growth.

2016年11月27日 · Fibroblast growth factor-binding protein 1 (FGFBP1) is a secreted chaperone that mobilizes paracrine-acting FGFs, stored in the extracellular matrix, and presents them to their cognate receptors. FGFBP1 enhances FGF signaling including angiogenesis during cancer progression and is upregulated in various cancers.

2017年11月20日 · A genetic polymorphism in the human FGFBP1 gene was associated with higher gene expression and an increased risk of familial hypertension. Here, we report on the effects of inducible BP1 expression in a transgenic mouse model.