Fibroblast growth factor 13 is a protein that in humans is encoded by the FGF13 gene. [5] [6] The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family.

2024年12月25日 · FGF13 (Fibroblast Growth Factor 13) is a Protein Coding gene. Diseases associated with FGF13 include Developmental And Epileptic Encephalopathy 90 and Intellectual Developmental Disorder, X-Linked 110. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and GPCR Pathway.

2012年6月22日 · We show that FGF13 acts intracellularly as a microtubule-stabilizing protein required for axon and leading process development and neuronal migration in the cerebral cortex. FGF13 is enriched in axonal growth cones and interacts directly with microtubules.

2024年11月1日 · Fibroblast Growth Factor (FGF) 13, also referred to as FGF homologous factor (FHF) 2, is a member of the FGF11 subfamily that is characterized as having sequence similarities to classical FGF receptor (FGFR)-binding FGFs, but functionally do not bind FGFRs.

FGF13 overexpression improves cognitive dysfunction in Aβ-induced rats. To investigate the role of FGF13 in the Aβ-induced rats, LV-FGF13 or LV-NC was stereotaxically injected into the bilateral hippocampus of healthy rats.

FGF13 enhances the function of TRPV1 by stabilizing microtubules and regulates acute and chronic itch. A Heterozygous Variant of FGF13 Caused X-Linked Developmental and Epileptic Encephalopathy 90 in a Chinese Family.

2021年10月23日 · We revealed that endogenous FGF13 is up-regulated in cardiac hypertrophy accompanied by increased nuclear localization. The upregulation of FGF13 plays a deteriorating role both in hypertrophic cardiomyocytes and mouse hearts.

Fibroblast Growth Factor (FGF) 13, also referred to as FGF homologous factor (FHF) 2, is a member of the FGF11 subfamily that is characterized as having sequence similarities to classical FGF receptor (FGFR)-binding FGFs, but functionally do not bind FGFRs.

2021年9月28日 · Here, we found that FGF13 was associated with poor platinum‐based chemotherapy outcomes in a variety of cancers, such as lung, endometrial, and cervical cancers, through bioinformatics analysis.

2024年6月17日 · FGF13 enhances resistance to platinum drugs by regulating hCTR1 and ATP7A via a microtubule-stabilizing effect. Expression and cellular distribution of FGF13 in cortical tubers of the tuberous sclerosis complex. Wu K, Yue J, Shen K, He J, Zhu G, Liu S, Yang H, Zhang CQWu K, et al. Neurosci Lett, 2021 Apr 1. PMID 33582188.