Fibroblast growth factor 19 is a protein that in humans is encoded by the FGF19 gene. [5] It functions as a hormone, regulating bile acid synthesis, with effects on glucose and lipid metabolism. Reduced synthesis, and blood levels, may be a factor in chronic bile acid diarrhea and in certain metabolic disorders.

Fibroblast Growth Factor 19/15 Yujie Bai, Yue Dai* China Pharmaceutical University, Nanjing Jiangsu Received: Apr. 6th, 2022; accepted: May 3rd, 2022; published: May 10th, 2022 Abstract FGF19 (FGF15 in rodents), a member of the endocrine FGF family, is …

成纤维细胞生长因子19 （FGF19）亚家族包含FGF19、FGF21、FGF23三种蛋白，它们对 FGFR1c 、2c、3c和4受体显示活性，但不能与FGFR1b、2b和3b受体结合。 （数据来源Dolegowska K, et al. J Physiol Biochem. 2019） 与经典的FGF亚家族成员不同，FGF19亚家族蛋白仅具有微弱的肝素结合亲和力或没有肝素结合亲和力，这使它们 ...

Fibroblast growth factor 19 (FGF19) is a gut hormone with pleiotropic effects. 77 It is secreted by the small intestine in response to feeding. FGF19 has insulinlike actions, such as promoting glucose uptake in adipocytes, synthesizing hepatic glycogen, and inhibiting gluconeogenesis. It also has a role in bile acid homeostasis and hepatic ...

2024年12月25日 · FGF19 (Fibroblast Growth Factor 19) is a Protein Coding gene. Diseases associated with FGF19 include Alagille Syndrome 1 and Functional Diarrhea.Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and GPCR Pathway.Gene Ontology (GO) annotations related to this gene include growth factor activity and fibroblast growth factor receptor binding.

We have identified a novel fibroblast growth factor, FGF-19, the most distant member of the FGF family described to date. FGF-19 is a high affinity, heparin dependent ligand for FGFR4 and is the first member of the FGF family to show exclusive binding to FGFR4. Human FGF-19 maps to chromosome 11 q13.1, a region associated with an osteoporosis ...

成纤维细胞生长因子19(fibroblast growth factor 19,FGF19)是在回肠末端特异性合成并分泌的细胞因子,属于FGFs的特殊成员之一。近年来自动物及细胞学的研究发现,FGF19不仅在胆汁酸代谢的调节中发挥重要作用,而且与多种心血管疾病危险因素密切相关。流行病学研究显示,2型糖尿病、代谢综合征及肥胖者FGF19 ...

成纤维细胞生长因子 19： 该基因编码的蛋白质是成纤维细胞生长因子 (fgf) 家族的成员。 fgf 家族成员具有广泛的促有丝分裂和细胞存活活性，并参与多种生物学过程，包括胚胎发育细胞生长、形态发生、组织修复、肿瘤生长和侵袭。该生长因子是 fgfr4 的高亲和力、肝素依赖性配体。

1 FGF19的生物学特性. FGF19是一种非典型的FGFs，与FGF21和FGF23同为内分泌FGFs。FGF19的啮齿动物同源基因被命名为FGF15，由于FGF15和FGF19能同时激活人和鼠成纤维细胞生长因子受体（fibroblast growth factor receptors，FGFRs），因此为研究外源性FGF19对鼠体内代谢的影响提供了一个模型系统 [1,2] 。

FGF-19 蛋白通过正调节 JNK 和 ERK1/2 级联抑制 CYP7A1 表达，在调节胆汁酸生物合成中发挥至关重要的作用。它刺激脂肪细胞中的葡萄糖摄取，依赖于 KLB 和 FGFR4。FGF-19 Protein, Human (His) 是重组的 FGF-19 蛋白，由 E. coli 表达，带有 N-6*His 标签。