Dec 25, 2024 · FCRL5 (Fc Receptor Like 5) is a Protein Coding gene. Diseases associated with FCRL5 include Hairy Cell Leukemia and Lymphoma. Among its related pathways is Extrafollicular and follicular B cell activation by SARS-CoV-2. An important paralog of this gene is FCRL3.

Jan 12, 2024 · Fc receptor-like 5 (FCRL5) is a protein marker with considerably upregulated expression in MM and has emerged as a promising target for CAR-T cell therapeutic interventions, offering an...

Apr 30, 2019 · In infected mice, FCRL5 is expressed on the majority of antigen-specific germinal-center-derived memory B cells (MBCs). Upon challenge, FCRL5 + MBCs rapidly give rise to antibody-producing cells expressing additional atypical markers, demonstrating functionality in …

Feb 8, 2025 · FCRL5 is a new type of receptor that recognizes intact IgG, possibly enabling B cells to sense Ig quality. Recognition of undamaged IgG molecules by FCRL5 could allow B cells to engage recently produced Abs. FcRL5 binds all …

By generating B cell-specific Fcrl5 transgenic mice, we demonstrated that Fcrl5 overexpression in B cells caused systemic autoimmunity with age. Additionally, Fcrl5 upregulation in B cells exacerbated the systemic lupus erythematosus-like disease model.

Jan 4, 2025 · Title: FCRL5 Delineates Functionally Impaired Memory B Cells Associated with Plasmodium falciparum Exposure. FCRL5 is a new type of receptor that recognizes intact IgG, possibly enabling B cells to sense Ig quality.

FCRL5 is the largest of the FCRL proteins with six D1 domains, a D3, D4, and D5 domain. It also has two ITIM sequences and one ITAM sequence in its intracellular region. Finally, FCRL6 has domains D1, D3, and D4 as well as one ITIM sequence in its cytoplasmic tail ( Figure 1 ).

Nov 2, 2023 · We tested four FCRL5 CAR-T (4-1BB CD3z) predicted to target distinct D9 epitopes and observed high cytolytic activity in killing assays using OPM2-CG-FCRL5 target cells. We tested each in vivo by injecting NSG mice in with OPM2-CG and 18 …

FCRL5+ atypical memory B cells (MBCs) expand in many chronic human diseases. Using tetramers to track rare antigen-specific cells, Kim et al. show that FCRL5+ MBCs are mature, optimally responsive cells that arise not only in response to infection and protein immunization in mice but also to immunization in humans.

Fc receptor-like (FCRL) proteins are novel regulators of the B cell response to antigen. Human FCRL5 binds intact IgG and modifies the strength of antigen receptor (BCR) signaling. Altering FCRL5 expression could therefore regulate the B cell response to antigen.