
FBXW7 - Wikipedia
F-box/WD repeat-containing protein 7 is a protein that in humans is encoded by the FBXW7 gene. [5][6][7] This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box.
FBXW7 Gene - GeneCards | FBXW7 Protein | FBXW7 Antibody
2024年12月25日 · FBXW7 (F-Box And WD Repeat Domain Containing 7) is a Protein Coding gene. Diseases associated with FBXW7 include Developmental Delay, Hypotonia, And Impaired Language and Colorectal Cancer. Among its related pathways are Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants and Class I MHC mediated antigen processing and …
Clinical significance of FBXW7 loss of function in human cancers
FBXW7 (F-Box and WD Repeat Domain Containing 7) (also referred to as FBW7 or hCDC4) is a component of the Skp1-Cdc53 / Cullin-F-box-protein complex (SCF/β-TrCP). As a member of the F-box protein family, FBXW7 serves a role in ...
FBXW7: a critical tumor suppressor of human cancers - PubMed
2018年8月7日 · FBXW7 is a critical tumor suppressor and one of the most commonly deregulated ubiquitin-proteasome system proteins in human cancer. FBXW7 controls proteasome-mediated degradation of oncoproteins such as cyclin E, c-Myc, Mcl-1, mTOR, Jun, Notch and AURKA.
FBXW7: a critical tumor suppressor of human cancers
2018年8月7日 · FBXW7 is a critical tumor suppressor and one of the most commonly deregulated ubiquitin-proteasome system proteins in human cancer. FBXW7 controls proteasome-mediated degradation of oncoproteins such as cyclin E, c-Myc, Mcl-1, mTOR, Jun, Notch and AURKA.
FBXW7 in Cancer: What Has Been Unraveled Thus Far? - PMC
The FBXW7 (F-box with 7 tandem WD40) protein encoded by the gene FBXW7 is one of the crucial components of ubiquitin ligase called Skp1-Cullin1-F-box (SCF) complex that aids in the degradation of many oncoproteins via the ubiquitin-proteasome system …
FBXW7 tumor suppressor regulation by dualspecificity tyrosine
2023年3月18日 · FBXW7 is a main tumor suppressor due to its ability to control proteasome-mediated degradation of several oncoproteins such as c-Jun, c-Myc, Cyclin E1, mTOR, and Notch1-IC. FBXW7 inactivation...
FBXW7 attenuates tumor drug resistance and enhances the …
Through degradation of its substrates, FBXW7 plays a pivotal role in drug resistance in tumor cells and shows the potential to rescue the sensitivity of cancer cells to drug treatment. This explains why patients with higher FBXW7 levels exhibit higher survival times and …
FBXW7 and the Hallmarks of Cancer: Underlying Mechanisms and ...
2022年4月18日 · In this review, we mainly elaborate on seven hallmarks of cancer influenced by FBXW7, including maintaining growth signals, resisting cell death, inducing angiogenesis, activating invasion and metastasis, reprogramming energy metabolism, avoiding immune destruction, and genome instability and mutation.
FBXW7 F-box and WD repeat domain containing 7 [ (human)]
2025年2月9日 · FBXW7 polymorphism asserts susceptibility to colorectal cancer. Fbxw7 suppresses carcinogenesis and stemness in triple-negative breast cancer through CHD4 degradation and Wnt/beta-catenin pathway inhibition. FBXW7 inhibits the progression of ESCC by directly inhibiting the stemness of tumor cells.