FOXO3a from the Nucleus to the Mitochondria: A Round Trip in …
In this review, we describe the multiple roles of FOXO3a in cellular stress response, with a focus on both its nuclear and mitochondrial functions. Keywords: FOXO3a, transcription factors, …
FOXO3 Gene - GeneCards | FOXO3 Protein | FOXO3 Antibody
Dec 25, 2024 · FOXO3 (Forkhead Box O3) is a Protein Coding gene. Diseases associated with FOXO3 include Hematologic Cancer and Aging. Among its related pathways are IL-9 …
FoxO3a and disease progression - PMC - PubMed Central (PMC)
FoxO3a has been found to be deregulated in several diseases and FoxO3a targeting approaches are currently underway to treat various types of cancers. This review will describe the current …
FoxO3a and disease progression - PubMed
Aug 26, 2014 · FoxO3a alteration is closely linked to the progression of several types of cancers, fibrosis and other types of diseases. In this review, we will examine the function of FoxO3a in …
FOXO3a from the Nucleus to the Mitochondria: A Round Trip in ... - PubMed
Sep 19, 2019 · The transcription factor Forkhead box protein O3 (FOXO3a) is a core regulator of cellular homeostasis, stress response, and longevity since it can modulate a variety of stress …
Longevity Factor FOXO3: A Key Regulator in Aging-Related …
The nuclear retention of transcription factor FOXO3a correlates with a DNA damage response and increased glutamine synthetase expression by astrocytes suggesting a neuroprotective …
FOXO3a regulates reactive oxygen metabolism by inhibiting
Dec 2, 2011 · FOXO3a activation blocked the hypoxia-dependent increase in ROS and prevented HIF-1 α stabilisation. Our data suggest that FOXO factors regulate mitochondrial activity …
FOXO3a regulates BNIP3 and modulates mitochondrial calcium, dynamics ...
Dec 1, 2016 · The forkhead box O3a (FOXO3a) transcription factor has been shown to regulate glucose metabolism, muscle atrophy, and cell death in postmitotic cells. Its role in regulation of …
FOXO3a functions as a transcriptional and co-transcriptional …
Apr 30, 2024 · Forkhead box O3a (FOXO3a, also known as FOXO3), a subfamily of the FOXO family, has been extensively studied for its unique and pivotal regulation of apoptosis, cell …
The dual missions of FoxO3a in inflammatory diseases: Regulation …
FoxO3a plays a central regulatory role in IPF by inhibiting fibroblast activation, differentiation, and extracellular matrix deposition, thereby suppressing fibrosis. Its downregulation is associated …
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