2024年12月25日 · FLT4 (Fms Related Receptor Tyrosine Kinase 4) is a Protein Coding gene. Diseases associated with FLT4 include Lymphatic Malformation 1 and Congenital Heart …

The FLT4 gene provides instructions for making a protein called vascular endothelial growth factor receptor 3 (VEGFR-3), which regulates the development and maintenance of the lymphatic …

Rare, deleterious genetic variants in FLT4 are associated with Tetralogy of Fallot (TOF), the most common cyanotic congenital heart disease. The distinct genetic variants in FLT4 are also an …

The AMPK agonist AICAR could rescue glycolytic reprogramming and inflammasome activation in macrophages expressing the mutant FLT4, which has potential translational application in …

our findings contribute to the putative targets in which the FLT4 gene mutation was found to have a significant role in lymphatic filariasis, while FOXC2 and FLT4 SNP interactions need to be …

2023年7月25日 · VEGFR3 (also known as FLT4) has a similar structure but is proteolytically cleaved in the extracellular domain during synthesis, resulting in the generation of a disulfide …

2024年9月2日 · FLT4 variants give rise to conditions of the two circulatory subdivisions of the vascular system via distinct developmental pleiotropic molecular mechanisms. Keywords: …

2023年11月23日 · This gene encodes a tyrosine kinase receptor for vascular endothelial growth factors C and D. The protein is thought to be involved in lymphangiogenesis and maintenance …

Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and …

This study presents FLT4 mutation findings from whole-exome sequencing (WES) analysis of a cohort of 29 MD patients. The patients underwent indocyanine green (ICG) lymphography …