2024年12月25日 · FLT4 (Fms Related Receptor Tyrosine Kinase 4) is a Protein Coding gene. Diseases associated with FLT4 include Lymphatic Malformation 1 and Congenital Heart Defects, Multiple Types, 7. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and GPCR Pathway.

The FLT4 gene provides instructions for making a protein called vascular endothelial growth factor receptor 3 (VEGFR-3), which regulates the development and maintenance of the lymphatic system. Learn about this gene and related health conditions.

Rare, deleterious genetic variants in FLT4 are associated with Tetralogy of Fallot (TOF), the most common cyanotic congenital heart disease. The distinct genetic variants in FLT4 are also an established cause of Milroy disease, the most prevalent form of primary hereditary lymphoedema.

The AMPK agonist AICAR could rescue glycolytic reprogramming and inflammasome activation in macrophages expressing the mutant FLT4, which has potential translational application in patients carrying Flt4 mutations to prevent recurrent infections. Collectively, we have elucidated that the FLT4-AMPK module in macrophages coordinates glycolytic ...

our findings contribute to the putative targets in which the FLT4 gene mutation was found to have a significant role in lymphatic filariasis, while FOXC2 and FLT4 SNP interactions need to be further elucidated at a functional level.

2023年7月25日 · VEGFR3 (also known as FLT4) has a similar structure but is proteolytically cleaved in the extracellular domain during synthesis, resulting in the generation of a disulfide bridge between the two...

2024年9月2日 · FLT4 variants give rise to conditions of the two circulatory subdivisions of the vascular system via distinct developmental pleiotropic molecular mechanisms. Keywords: Congenital heart disease; Developmental pleiotropy; FLT4; Primary lymphoedema; Proteostasis; Tetralogy of Fallot; VEGFR3.

2023年11月23日 · This gene encodes a tyrosine kinase receptor for vascular endothelial growth factors C and D. The protein is thought to be involved in lymphangiogenesis and maintenance of the lymphatic endothelium. Mutations in this gene cause hereditary lymphedema type IA. [provided by RefSeq, Jul 2008]

Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting.

This study presents FLT4 mutation findings from whole-exome sequencing (WES) analysis of a cohort of 29 MD patients. The patients underwent indocyanine green (ICG) lymphography examination to localize and characterize lymphatic defects in their affected limbs.