FKBP1A (also known as FKBP12) is notable in humans for binding the immunosuppressant molecule tacrolimus (originally designated FK506), which is used in treating patients after …

It is also commonly referred to as FKBP-12 or FKBP12 and is a member of a family of FK506-binding proteins .

FKBP12, the 12-kDa FK506-binding protein, is a ubiquitous abundant protein that acts as a receptor for the immunosuppressant drug FK506, binds tightly to intracellular calcium release …

In this review, we have summarized the information from a study on FKBP12 (FK506 binding protein 12 kDa) with a view to understand its drug-free, physiological roles in transcription of …

FK506 binding proteins (FKBPs) are a family of highly conserved proteins in eukaryotes. The prototype of this protein family, FKBP12, is the binding partner for immunosuppressive drugs …

Dec 22, 2022 · The primary target of FK506 in cells is FKBP12; therefore, we tested whether SLF and rapamycin, other FKBP12 inhibitors, can recapitulate the activity of FK506. Both …

Jun 15, 2002 · Results: We found that growth inhibition induced by FK506 is abolished in FKBP12-deficient cells but not in FKBP12.6-deficient cells. Conclusions: FKBP12 is the only …

FKBP12 and various targets show differences in the FKBP12 binding surface, 26 providing a high degree of flexibility and improving the odds of binding with additional targets.

Dec 5, 2018 · FKBP12 and FKBP12.6 are well documented components of RyR complexes, which intracellularly amplify Ca 2+-signaling in myocytes to evoke muscle contraction.

Nov 18, 2021 · FKBP12 was first described in 1989 by Harding et al. and Siekierka et al. . With a molecular weight of 12 kDa, it is the smallest member of the FKBP family. It contains the …