FKBP1A (also known as FKBP12) is notable in humans for binding the immunosuppressant molecule tacrolimus (originally designated FK506), which is used in treating patients after …

It is also commonly referred to as FKBP-12 or FKBP12 and is a member of a family of FK506-binding proteins .

FKBP12, the 12-kDa FK506-binding protein, is a ubiquitous abundant protein that acts as a receptor for the immunosuppressant drug FK506, binds tightly to intracellular calcium release …

In this review, we have summarized the information from a study on FKBP12 (FK506 binding protein 12 kDa) with a view to understand its drug-free, physiological roles in transcription of …

2001年2月20日 · FKBP12, the 12-kDa FK506-binding protein, is a ubiquitous abundant protein that acts as a receptor for the immunosuppressant drug FK506, binds tightly to intracellular …

FK506 binding proteins (FKBPs) are a family of highly conserved proteins in eukaryotes. The prototype of this protein family, FKBP12, is the binding partner for immunosuppressive drugs …

The prototype of this protein family, FKBP12, is the binding partner for immunosuppressive drugs FK506 and rapamycin. FKBP12 functions as a cis/trans peptidyl prolyl isomerase (PPIase) …

2020年5月21日 · The 12-kDa FK506-binding protein (FKBP12) is the target of the commonly used immunosuppressive drug FK506. The FKBP12-FK506 complex binds to calcineurin and …

2022年12月22日 · The primary target of FK506 in cells is FKBP12; therefore, we tested whether SLF and rapamycin, other FKBP12 inhibitors, can recapitulate the activity of FK506. Both …

2018年12月5日 · FKBP12 and FKBP12.6 are well documented components of RyR complexes, which intracellularly amplify Ca 2+-signaling in myocytes to evoke muscle contraction.

Know comprehensive FKBP12 protein information including protein sequence, molecular weight, theoretical pI, structure, function and protein interaction.

The immunophilin FKBP12 binds to TGF-β family type I receptors, including the BMP type I receptor ALK2. FKBP12 keeps the type I receptor in an inactive state and controls signaling …

2023年1月12日 · The most recently discovered natural FKBP12 ligand, WDB002, was identified in 2020 as a potential FKBP12-binding partner when the genomes of Streptomyces malaysiensis …

2002年6月15日 · Results: We found that growth inhibition induced by FK506 is abolished in FKBP12-deficient cells but not in FKBP12.6-deficient cells. Conclusions: FKBP12 is the only …

2011年3月3日 · To investigate the physiological role of FKBP12 in the heart, we created and analyzed cardiomyocyte-restricted FKBP12 conditional knockout (FKBP12 f/f /αMyHC-Cre) …

Some of the most studied regulatory proteins are FK506-binding proteins (FKBPs), which are cis-trans peptidi l-prolyl isomerases that bind the immunosuppressant drugs FK506 (Tacrolimus) …

FK506 binding (FKBP) proteins are part of the highly conserved immunophilin family and its members have fundamental roles in the regulation of signalling pathways involved in …

2018年3月27日 · The binding of Ca 2+ to the EF-hand domain of FKBP12 or FKBP12.6 facilitates the transmembrane helices to form a pore and increases the plausibility of gate opening with …

2011年4月4日 · We generated FKBP12 overexpressing transgenic (αMyHC-FKBP12) mice and cardiomyocyte-restricted FKBP12 conditional knockout (FKBP12 f/f /αMyHC-Cre) mice, and …

2023年1月30日 · The immunophilin FKBP12 binds to TGF-β family type I receptors, including the BMP type I receptor ALK2. FKBP12 keeps the type I receptor in an inactive state and controls …