FGF19 - Wikipedia
Fibroblast growth factor 19 is a protein that in humans is encoded by the FGF19 gene. [5] It functions as a hormone, regulating bile acid synthesis, with effects on glucose and lipid …
FGF19：亟待开发的临床价值 - 知乎 - 知乎专栏
成纤维细胞生长因子19（FGF19）亚家族包含FGF19、FGF21、FGF23三种蛋白，它们对FGFR1c、2c、3c和4受体显示活性，但不能与FGFR1b、2b和3b受体结合。 与经典的FGF亚 …
FGF19 Gene - GeneCards | FGF19 Protein | FGF19 Antibody
Dec 25, 2024 · FGF19 (Fibroblast Growth Factor 19) is a Protein Coding gene. Diseases associated with FGF19 include Alagille Syndrome 1 and Functional Diarrhea . Among its …
FGF19 (FGF15 in rodents), a member of the endocrine FGF family, is an intestinal hormone involved in the regulation of bile acid, glucose and lipid metabolism to maintain systemic …
FGF19/FGFR4信号通路与原发性肝细胞肝癌（HCC） - 知乎专栏
研究显示， ponatinib靶向FGF19/FGFR4轴，通过增强索拉非尼治疗的HCC中ros相关的凋亡，可以克服索拉非尼的HCC耐药性。 我国是肝癌大国，肝细胞癌（HCC）是占比最高的肝癌类型 …
成纤维细胞生长因子19 (FGF19)与脂代谢的研究进展
成纤维细胞生长因子19(fibroblast growth factor 19,FGF19)是在回肠末端特异性合成并分泌的细胞因子,属于FGFs的特殊成员之一。 近年来自动物及细胞学的研究发现,FGF19不仅在胆汁酸代 …
FGF19：亟待开发的临床价值 - CSDN博客
Aug 19, 2024 · fgf19也可能是筛查肺癌的新诊断指标，与fgfr4结合驱动肺鳞状细胞癌（lsq）的进展。 为FGF19驱动的LSQ中使用阻断FGF19/FGFR4信号轴疗法提供了新思路。 （ 数据来源Li …
Metabolic Messengers: fibroblast growth factor 15/19 - Nature
Jun 14, 2019 · Fibroblast growth factor (FGF) 15 in mice and its human orthologue FGF19 (together denoted FGF15/19) are gut hormones that control homeostasis of bile acids and …
靶向 FGF19-FGFR4 通路治疗胆汁淤积、代谢和癌性疾病,Journal of …
本综述旨在提供针对胆汁淤积、代谢和癌症疾病患者靶向 FGF19-FGFR4 信号通路的类似物和拮抗剂临床开发的最新信息。 我们还将分析潜在的安全性和机制问题，这些问题应指导未来的研 …
The FGF family: biology, pathophysiology and therapy - PMC
Several mitogenic, cytoprotective and angiogenic therapeutic applications of FGFs are already being explored, and the recent discovery of the crucial roles of the endocrine-acting FGF19 …