Fibroblast growth factor 10 is a paracrine signaling molecule seen first in the limb bud and organogenesis development. FGF10 starts the developing of limbs and its involved in the branching of morphogenesis in multiple organs such as the lungs, skin, ear and salivary glands.

2024年12月25日 · FGF10 (Fibroblast Growth Factor 10) is a Protein Coding gene. Diseases associated with FGF10 include Aplasia Of Lacrimal And Salivary Glands and Lacrimoauriculodentodigital Syndrome 3. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and Downstream signaling of activated FGFR2.

The FGF10 gene provides instructions for making a protein called fibroblast growth factor 10 (FGF10). Learn about this gene and related health conditions.

2016年4月1日 · FGF10 is a mesenchymal signaling molecule in the epithelium. FGF10 knockout mice die shortly after birth due to the complete absence of lungs as well as fore- and hindlimbs. FGF10 is also essential for the development of multiple organs.

Fgf10 is an epithelial-mesenchymal signaling molecule. Fgf10 knockout mice show severe phenotypes with complete truncation of the fore- and hindlimbs and die shortly after birth due to impaired lung development, indicating that Fgf10 serves as an essential regulator of …

Fibroblast growth factor 10 attenuates chronic obstructive pulmonary disease by protecting against glycocalyx impairment and endothelial apoptosis. FGF10 promotes cardiac repair through a dual cellular mechanism increasing cardiomyocyte renewal and inhibiting fibrosis.

Fibroblast growth factor 10 (FGF10) is a major morphoregulatory factor that plays essential signaling roles during vertebrate multiorgan development and homeostasis. FGF10 is predominantly expressed in mesenchymal cells and signals though FGFR2b in adjacent epithelia to regulate branching morphogene …

2024年12月10日 · Title: FGF10/FGFR2 Signaling: Therapeutically Targetable Vulnerability in Ligand-responsive Cholangiocarcinoma Cells. Fibroblast growth factor 10 attenuates chronic obstructive pulmonary disease by protecting against glycocalyx impairment and …

2019年2月7日 · The occurrence of rare coding variants involving TBX4 or FGF10 with the putative hypomorphic non-coding SNVs implies a complex compound inheritance of these pulmonary hypoplasias.

Recent studies have indicated a significant role of TBX4 and FGF10 dosage in the development of CAD and other diseases e.g. acinar dysplasia from the LLDD spectrum. 3–9 Heterozygous abnormalities involving FGF10 are characteristically found in patients with lacrimo-auriculo-dento-digital syndrome (MIM#620193) or aplasia of the lacrimal and ...