Fibroblast growth factor 2 (FGF-2), also known as basic fibroblast growth factor (bFGF) and FGF-β, is a growth factor and signaling protein encoded by the FGF2 gene. [5] [6] It binds to and exerts effects via specific fibroblast growth factor receptor (FGFR) proteins, themselves a family of closely related molecules.

Basic fibroblast growth factor (FGF)-2 has been shown to regulate many cellular functions including cell proliferation, migration, and differentiation, as well as angiogenesis in a variety of tissues, including skin, blood vessel, muscle, adipose, tendon/ligament, cartilage, bone, …

Acidic FGF (FGF1) and basic FGF (FGF2) were originally isolated from the brain and pituitary gland as growth factors for fibroblasts. Since then, at least 22 distinct FGFs have been identified or isolated. FGFs have been found in both vertebrates and invertebrates.

2020年9月2日 · FGFs exert their pleiotropic effects by binding and activating high-affinity tyrosine kinase receptors that are coded by four genes (FGFR1, FGFR2, FGFR3, and FGFR4) and FGFRL1, a truncated FGFR...

Fibroblast growth factor 2 (FGF2) is a protein produced by human cells that exerts molecular effects through its specific receptors. The main roles of these molecules are represented by cell growth, tissue repair, wound healing, tumor growth and angiogenesis [1]. The interaction between PTX3 and FGF2 results in the genesis of PTX3/FGF2 complex.

2017年1月6日 · FGF2 is the prototype member of the FGF family and interacts with its receptor to mediate receptor dimerization, phosphorylation, and activation of signaling pathways, such as Ras-MAPK and PI3K pathways.

2024年12月25日 · FGF2 (Fibroblast Growth Factor 2) is a Protein Coding gene. Diseases associated with FGF2 include Corneal Neovascularization and Long Qt Syndrome. Among its related pathways are Downstream signaling of activated FGFR2 and Apoptotic Pathways in Synovial Fibroblasts.

FGF-2 expression in malformations of cortical development reflects incomplete differentiation and maturation of dysplastic cells; FGF2 was among the genes differentially expressed in an in vivo-in vivo comparison between unfused and prematurely fused calvarial tissue.

2020年7月1日 · Title: The optimized priming effect of FGF-1 and FGF-2 enhances preadipocyte lineage commitment in human adipose-derived mesenchymal stem cells. Serum fibroblast growth factor-2 levels complement vital biomarkers for diagnosing heart failure.

FGF-2 stimulates the growth and development of new blood vessels (angiogenesis) that contribute to the pathogenesis of several diseases (i.e. cancer, atherosclerosis), normal wound healing and tissue development.