The serine/threonine-protein kinase/endoribonuclease inositol-requiring enzyme 1 α (IRE1α) is an enzyme that in humans is encoded by the ERN1 gene. [5][6] The protein encoded by this gene is the ER to nucleus signalling 1 protein, a human homologue of the yeast Ire1 gene product.

2024年12月25日 · ERN1 (Endoplasmic Reticulum To Nucleus Signaling 1) is a Protein Coding gene. Diseases associated with ERN1 include Epiphyseal Dysplasia, Multiple, With Early-Onset Diabetes Mellitus and Alzheimer's Disease. Among its related pathways are Alzheimer's disease and miRNA effects and Cellular responses to stimuli.

ERN1 and ALPK1 inhibit differentiation of bi-potential tumor-initiating cells in human triple negative breast cancer. IRE1 deficiency fully restored the learning and memory capacity of AD mice, associated with improved synaptic function and improved long-term potentiation (LTP).

2025年2月9日 · This gene encodes the transmembrane protein kinase inositol-requiring enzyme 1. The encoded protein contains two functional catalytic domains, a serine/threonine-protein kinase domain and an endoribonuclease domain.

2025年2月9日 · Title: Inhibition of signaling protein ERN1 increases the sensitivity of serine synthesis gene expressions to glucose and glutamine deprivations in U87MG glioblastoma cells. IRE1alpha recognizes a structural motif in cholera toxin to activate an unfolded protein response.

Here we report that ERN1 (endoplasmic reticulum to nucleus signaling 1), which is upregulated by UPR (unfolded protein response), targets an RNA hairpin loop motif in EGFP mRNA. A silent mutation introduced into EGFP mRNA abolished the ERN1‐dependent mRNA decay.

2021年6月1日 · Here, we review the biology of Inositol-requiring enzyme 1β (IRE1β), an ER-resident endonuclease and paralogue of the most evolutionarily conserved ER stress sensor IRE1α.

2024年11月27日 · In summary, ERN1 is a key sensor in the unfolded protein response, detecting ER stress and activating transcriptional programs that restore balance in the cell. Its highly conserved role in splicing XBP1 mRNA makes it a critical regulator of cellular stress responses, highlighting its biological importance in maintaining protein homeostasis ...

2018年11月27日 · We identify loss of the endoplasmic reticulum (ER) stress sensor IRE1 as synthetic lethal with activated RAS mutants in yeast. In KRAS mutant colorectal cancer cell lines, genetic ablation of the human ortholog of IRE1, ERN1, does …

2016年9月14日 · Gene target information for ERN1 - endoplasmic reticulum to nucleus signaling 1 (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.