
ERBB4 Gene - GeneCards | ERBB4 Protein | ERBB4 Antibody
2024年12月25日 · ERBB4 (Erb-B2 Receptor Tyrosine Kinase 4) is a Protein Coding gene. Diseases associated with ERBB4 include Amyotrophic Lateral Sclerosis 19 and …
ERBB4 - Wikipedia
ERBB4 is a single-pass type I transmembrane protein with multiple furin-like cysteine rich domains, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ …
A Review of HER4 (ErbB4) Kinase, Its Impact on Cancer, and Its ...
HER4, also known as ErbB4, is a member of epidermal growth factor receptor (EGFR) or ErbB family. HER4 is necessary for normal development of body systems including heart, nervous …
The role of ErbB4 in cancer - PubMed
Here, we discuss the role of ErbB4 in normal physiology and in breast, lung, colorectal, gastric, pancreatic, prostate, bladder, and brain cancers, as well as in hepatocellular carcinoma, …
The Yin and Yang of ERBB4: Tumor Suppressor and Oncoprotein
We review the mechanisms of ERBB4 signaling with an emphasis on mechanisms of signaling specificity. In the context of this signaling specificity, we discuss the hypothesis that ERBB4 …
ErbB4 Signaling | GeneGlobe - Qiagen
ErbB4 is a 180-kDa transmembrane RTK that regulates cell proliferation and differentiation. The ErbB4 gene has been isolated as the fourth member of the human EGFR subfamily of tyrosine …
Erbb4 Signaling: an overlooked backup system? - PMC
This new study by Kurokawa and colleagues highlights the role ErbB4 signaling as a critical backup system in ErbB2+ breast cancers. This study implied that Pan-ERBB inhibitors have …
Profiling of ERBB receptors and downstream pathways reveals …
2024年2月16日 · Known effects were confirmed, and previously uncharacterized properties were discovered, such as pyrotinib’s preference for ERBB4 over EGFR. Additionally, two lead …
ERBB4 erb-b2 receptor tyrosine kinase 4 [ (human)]
ErbB4/KITENIN-Mediated Signaling is Activated in Cetuximab-Resistant Colorectal Cancer Cells. Her4 promotes cancer metabolic reprogramming via the c-Myc-dependent signaling axis. …
The Yin and Yang of ERBB4: Tumor Suppressor and Oncoprotein
We review the mechanisms of ERBB4 signaling with an emphasis on mechanisms of signaling specificity. In the context of this signaling specificity, we discuss the hypothesis that ERBB4 …