Receptor tyrosine-protein kinase erbB-3, also known as HER3 (human epidermal growth factor receptor 3), is a membrane bound protein that in humans is encoded by the ERBB3 gene. …

2024年12月25日 · ERBB3 (Erb-B2 Receptor Tyrosine Kinase 3) is a Protein Coding gene. Diseases associated with ERBB3 include Lethal Congenital Contracture Syndrome 2 and …

2021年1月15日 · erbb3（又称her3，人表皮生长因子受体3）是表皮生长因子受体家族（egfr）中的一员。erbb3基因位于人类第12号染色体的长臂上（12q13），其编码的蛋白分子量为160 …

erbb3是表皮生长因子受体家族 (egfr/erbb)中的一员，和其它egfr家族成员一样，由胞外配体结合域、跨膜结构域和胞内结构域3部分组成。 ErbB3可结合神经调节蛋白配体，但它不能通过蛋白 …

ERBB3, a member of the epidermal growth factor receptor (EGFR) family, is unique in that its tyrosine kinase domain is functionally defective. It is activated by neuregulins, by other ERBB …

2019年9月13日 · In this review, we discuss the evidence presenting ERBB3 somatic mutations as potential tumoral drivers. We then show that ERBB3 mutations are not uncommon in many …

ErbB3 has a role in cell proliferation in ovarian cancer. HER-3 expression is correlated with better prognosis in neuroendocrine cancer; erbB3 immunoreactivity was prominent in CD133-positive …

In this review, we discuss the evidence presenting ERBB3 somatic mutations as potential tumoral drivers. We then show that ERBB3 mutations are not uncommon in many cancer types. …

2024年9月1日 · Using preclinical and clinical evidence, we synthesise and explicate how various aspects of aberrant ERBB3 activities–such as compensatory activation, signal crosstalk …

ErbB (erythroblastic oncogene B) belongs to the epidermal growth factor receptor family and consists of an extracellular domain, a transmembrane domain, and a cytoplasmic tyrosine …