Receptor tyrosine-protein kinase erbB-3, also known as HER3 (human epidermal growth factor receptor 3), is a membrane bound protein that in humans is encoded by the ERBB3 gene. ErbB3 is a member of the epidermal growth factor receptor (EGFR/ERBB) family …

2024年12月25日 · ERBB3 (Erb-B2 Receptor Tyrosine Kinase 3) is a Protein Coding gene. Diseases associated with ERBB3 include Lethal Congenital Contracture Syndrome 2 and Visceral Neuropathy, Familial, 1, Autosomal Recessive. Among its related pathways are GPCR Pathway and Prolactin Signaling.

2021年1月15日 · erbb3（又称her3，人表皮生长因子受体3）是表皮生长因子受体家族（egfr）中的一员。erbb3基因位于人类第12号染色体的长臂上（12q13），其编码的蛋白分子量为160或180kda [2] 。erbb3和其它egfr家族成员一样，由胞外配体结合域、跨膜结构域和胞内结构域3部分 …

erbb3是表皮生长因子受体家族 (egfr/erbb)中的一员，和其它egfr家族成员一样，由胞外配体结合域、跨膜结构域和胞内结构域3部分组成。 ErbB3可结合神经调节蛋白配体，但它不能通过蛋白磷酸化来介导胞内信号转导。

ERBB3, a member of the epidermal growth factor receptor (EGFR) family, is unique in that its tyrosine kinase domain is functionally defective. It is activated by neuregulins, by other ERBB and nonERBB receptors as well as by other kinases, and by novel mechanisms.

2019年9月13日 · In this review, we discuss the evidence presenting ERBB3 somatic mutations as potential tumoral drivers. We then show that ERBB3 mutations are not uncommon in many cancer types. Finally, we...

ErbB3 has a role in cell proliferation in ovarian cancer. HER-3 expression is correlated with better prognosis in neuroendocrine cancer; erbB3 immunoreactivity was prominent in CD133-positive putative tumor stem cells.

In this review, we discuss the evidence presenting ERBB3 somatic mutations as potential tumoral drivers. We then show that ERBB3 mutations are not uncommon in many cancer types. Finally, we present the recent results of several studies evaluating different therapeutic approaches for treating patients with oncogenic ERBB3 mutations.

2024年9月1日 · Using preclinical and clinical evidence, we synthesise and explicate how various aspects of aberrant ERBB3 activities–such as compensatory activation, signal crosstalk interactions, dysregulation in the endocytic pathway, mutations, ligand-independent activation, intrinsic kinase activity, and homodimerisation–can lead to resistance development ...

ErbB (erythroblastic oncogene B) belongs to the epidermal growth factor receptor family and consists of an extracellular domain, a transmembrane domain, and a cytoplasmic tyrosine kinase domain. In humans, the ErbB family includes four members: ErbB1 (Her1), ErbB2 (Her2), ErbB3 (Her3), ErbB4 (Her4).