Epileptogenesis is the gradual process by which a typical brain develops epilepsy. [1] Epilepsy is a chronic condition in which seizures occur. [2] These changes to the brain occasionally cause neurons to fire in an abnormal, hypersynchronous manner, known as a seizure. [3]

Epileptogenesis is the process in which tissue develops and extends the ability to generate spontaneous seizures, leading to the development of epilepsy or the progression of existing epilepsy. It involves a cascade of molecular and cellular changes triggered by a brain-damaging insult, resulting in the occurrence of unprovoked seizures.

Epileptogenesis is a chronic process that can be triggered by genetic or acquired factors, and that can continue long after epilepsy diagnosis. In 2015, epileptogenesis is not a treatment indication, and there are no therapies available in clinic to treat individuals at risk of epileptogenesis.

Epileptogenesis is a complex multifactorial pathologic process underlying “the development and extension of brain tissue capable of generating spontaneous seizures” (Pitkänen and Engel, 2014); therefore, this process is responsible for the onset, development, and progression of epilepsy. In the last decade, advancement in understanding the ...

Epileptogenesis is the process through which neuronal networks are altered resulting in the generation of spontaneous, chronic seizures. Epileptogenesis is thought to involve three stages: 1) the initial insult or precipitating event, 2) the latent period, and 3) the chronic epilepsy phase.

Apr 18, 2013 · Substantial research has focused on elucidating the mechanisms of epileptogenesis so as to identify more specific targets for intervention, with the hope of preventing epilepsy before seizures...

Epileptogenesis is a long-drawn process that involves neuronal loss, axonal sprouting, glial cell activation, inflammation, changes in the extracellular matrix, and alterations in neurotransmitters and their receptors [67].

Epileptogenesis refers to the development and extension of tissue capable of generating spontaneous seizures, resulting in (a) the development of an epileptic condition and/or (b) progression of the epilepsy after it is established (Pitkänen and Engel Jr., 2014).

Feb 21, 2014 · The primary purpose of this topic is to collect scientific contributions providing novel insights in the cellular and molecular mechanisms of epileptogenesis as potential targets for innovative therapeutic approaches aimed at preventing the chronic epileptic disorder.

Sep 18, 2015 · Epileptogenesis is a chronic process that can be triggered by genetic or acquired factors, and that can continue long after epilepsy diagnosis. In 2015, epileptogenesis is not a treatment indication, and there are no therapies available in clinic to treat individuals at risk of epileptogenesis. Howe …