2024年12月25日 · EPHB4 (EPH Receptor B4) is a Protein Coding gene. Diseases associated with EPHB4 include Capillary Malformation-Arteriovenous Malformation 2 and Lymphatic Malformation 7. Among its related pathways are GPCR Pathway and EPH-Ephrin signaling.

13846 Ensembl ENSG00000196411 ENSMUSG00000029710 UniProt P54760 P54761 RefSeq (mRNA) NM_004444 NM_001159571 NM_010144 RefSeq (protein) NP_004435 NP_001153043 NP_034274 Location (UCSC) Chr 7: 100.8 – 100.83 Mb Chr 5: 137.35 – 137.38 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Ephrin type-B receptor 4 is a protein that in humans is encoded by the EPHB4 gene. Ephrin receptors ...

该研究显示 EphB4 (Eph receptor B4) 是一种调节细胞粘附和迁移的 酪氨酸激酶受体，可以直接与 InsR 结合，并且这种相互作用被胰岛素显著增强。 由于 EphB4 中的衔接蛋白 2 (adaptor protein 2, Ap2) 复合结合基序，EphB4 和 InsR 的相互作用促进了网格蛋白介导的 InsR 在溶酶体中的内吞作用和降解。 在肝脏过表达EphB4降低了食物喂养小鼠的 InsR 水平并增加了肝脏和全身 胰岛素抵抗，而 EphB4 的遗传或药理学抑制改善了肥胖小鼠的胰岛素抵抗和葡萄糖耐受不良。 这些结果 …

2022年6月20日 · We observe that manipulating the EphB4 intracellular domain on cancer cells accelerates tumor growth and angiogenesis. EphB4 cancer cell loss also triggers compensatory upregulation of EphA4...

This review discusses the structure and function of the EphB4 receptor, analyzes its potential as a target for anticancer therapy, and summarizes the information about inhibitors of EphB4 kinase activity. Conclusively, EphB4 is a challenging but promising therapeutic target in cancer.

本文阐述了 EphB4 受体的结构和功能，分析了其作为抗癌治疗靶点的可能性，并总结了 EphB4 激酶抑制剂的知识。 总而言之，EphB4 是一种困难但有潜力的癌症治疗选择。

In this study, we found a close relationship between EPHB4 and aging. Therefore, in-depth research on the relationship between EPHB4 and aging can help reveal the molecular mechanisms of aging and provide new ideas and methods for developing anti-aging drugs and treating vascular aging-related diseases.

2019年10月22日 · Here, we show that high expression of EPHB4 correlated with poor survival in prostate cancer patients and EPHB4 inhibition induced cell death in both hormone sensitive and castration-resistant...

2025年3月5日 · EphB4 and ephrin-B2 are induced in a PTEN-null mouse model of prostate cancer. To determine if EphB4 expression is regulated by PTEN loss-of-function and activation of the PI3K pathway, we used a ...

2024年9月19日 · Clinical resource with information about EPHB4, Capillary malformation-arteriovenous malformation 2, Capillary malformation-arteriovenous malformation syndrome, Genome-wide association study for circulating levels of PAI-1 provides novel insights into its regulation., Lymphatic malformation 7, and available tests.