With the discovery of endothelial progenitor cells (EPCs) in the late 1990s, a paradigm shift in the concept of neoangiogenesis occurred. The identification of circulating EPCs in peripheral blood marked the beginning of a new era with enormous ...

Human endothelial progenitor cells (EPCs) have been generally defined as circulating cells that express a variety of cell surface markers similar to those expressed by vascular endothelial cells, adhere to endothelium at sites of hypoxia/ischemia, and participate in new vessel formation.

Endothelial progenitor cells (EPCs) are currently being studied as candidate cell sources for revascularization strategies. Despite these promising results, widespread clinical acceptance of EPCs for clinical therapies remains hampered by several ...

Endothelial progenitor cells (EPCs) are a group of non-endothelial cells that can give rise to endothelial cells. Stemness of the cells is not clear, but they can be expanded, and increasing evidence shows that EPCs play a major role in postnatal neovascularization.

Endothelial progenitor cells are a population of stem cells that are mobilized from the bone marrow and home to specific sites (ischemic tissue or tumors) with the potential to differentiate into endothelial cells and promote angiogenesis.

Endothelial progenitor cells (EPCs) are immature cells with a capacity for proliferation, migration, and differentiation into endothelial cells (ECs) (Ribatti, 2007). Unlike ECs, EPCs show clonal expansion and stemness characteristics, including high proliferation and resistance to stress, and lack mature EC markers ( Dernbach et al., 2004; He ...

2011年5月24日 · Endothelial progenitor cells (EPCs) are bone marrow derived cells that can be found in the peripheral and umbilical cord blood and were first isolated using magnetic micro beads by Asahara [9].

2004年8月20日 · Infusion of different hematopoietic stem cell populations and ex vivo expanded endothelial progenitor cells augments neovascularization of tissue after ischemia and contributes to reendothelialization after endothelial injury, thereby, providing a novel therapeutic option.

2008年12月3日 · These landmark studies on endothelial progenitor cells (EPCs) thus challenged the traditional concept that endothelial regeneration and angiogenesis occurs exclusively via the proliferation of pre-existing resident vessel wall ECs, and thus it appeared that vasculogenesis also occurs in postnatal life.

Endothelial progenitor cells (EPCs): The name embodies years of research and clinical expectations, but where are we now? Do these cells really represent the El Dorado of regenerative medicine? Here, past and recent literature about this eclectic, ...