Nov 20, 2023 · The very-long-chain fatty acid elongase (ELOVL) family plays essential roles in lipid metabolism and cellular functions. This comprehensive review explores the structural characteristics, functional properties, and physiological significance of individual ELOVL isoforms, providing insights into lipid biosynthesis, cell membrane dynamics, and ...

Dec 24, 2024 · ELOVL1 (ELOVL Fatty Acid Elongase 1) is a Protein Coding gene. Diseases associated with ELOVL1 include Ichthyotic Keratoderma, Spasticity, Hypomyelination, And Dysmorphic Facial Features and Spinocerebellar Ataxia 38. Among its related pathways are Fatty acid metabolism and docosahexaenoate biosynthesis IV (4-desaturase, mammals).

超长链脂肪酸延长酶 (ELOVL) 家族在脂质代谢和细胞功能中发挥着重要作用。 这篇全面的综述探讨了各个 ELOVL 同工型的结构特征、功能特性和生理意义，为脂质生物合成、细胞膜动力学和信号通路提供了见解。 本综述旨在强调 ELOVL 家族在正常生理和疾病发展中的重要性。 通过综合当前的知识，我们强调了 ELOVL 作为潜在治疗靶点的相关性。 我们强调 ELOVL 表达失调与疾病之间的关联，包括代谢紊乱、皮肤病、神经退行性疾病和癌症。 ELOVL 在癌症生物学（从肿瘤 …

May 31, 2022 · Elovl2 是一种作为多不饱和脂肪酸 (PUFA) 合成的主要控制基因并与糖尿病等关键代谢异常密切相关。 并且它在衰老的生物年龄“时钟”里面所占权重最大， Elovl2的 DNA 甲基化状态解释了 70% 的“衰老表观遗传时钟”特征。 而且 Elovl2在不同的衰老组织中均体现了其甲基化程度与衰老的高度相关，在生物学年龄“时钟”中可以作为通用生物年龄标志物，而其余标志基因则通常具有组织特异性且在衰老预测中的权重较小。 在功能上， Elovl2 在多不饱和脂肪酸的合成 …

Jun 10, 2021 · To understand the molecular basis of acyl chain elongation by the ELOVL elongases, we purified and solved the crystal structure of human ELOVL7 in complex with a copurified, covalently bound...

Nov 20, 2023 · Background: The very-long-chain fatty acid elongase (ELOVL) family plays essential roles in lipid metabolism and cellular functions. This comprehensive review explores the structural characteristics, functional properties, and physiological significance of individual ELOVL isoforms, providing insights into lipid biosynthesis, cell membrane ...

超长链脂肪酸延伸酶 (elongase of verylong chain fatty acids,ELOVL)家族是哺乳动物中一类编码超长链脂肪酸 (very long chain fatty acids,VLCFA)延伸酶的基因家族。 该家族有7个成员:ELOVL1～7。 各个成员编码的蛋白质参与不同长度脂肪酸链的延长,对脂肪酸的代谢进行调控,进而发挥其生物学功能。 本文就该家族成员的结构、生物学功能及表达调控进行综述。 百度学术集成海量学术资源，融合人工智能、深度学习、大数据分析等技术，为科研工作者提供全面快捷的 …

Mar 1, 2025 · The FA elongation system is therefore fundamental for membrane biogenesis and lipid homeostasis, and also for signalling pathways associated with inflammation and cell proliferation. This review focuses on the elongase enzymes, encoded by the ELOVL genes, which catalyze the first and rate-limiting step of the FA elongation cycle. We summarize ...

Mar 8, 2023 · Elongation of very long-chain fatty acid (Elovl) proteins are key enzymes that catalyze the rate-limiting step in the fatty acid elongation pathway. The most recently discovered member of the Elovl family, Elovl8, has been proposed to be a fish-specific elongase with two gene paralogs described in teleosts.

Enables fatty acid elongase activity. Involved in fatty acid biosynthetic process and sphingolipid biosynthetic process. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]