The ternary complex factor (TCF) Elk-1 is a transcription factor that regulates immediate early gene (IEG) expression via the serum response element (SRE) DNA consensus site.

Dec 24, 2024 · ELK1 (ETS Transcription Factor ELK1) is a Protein Coding gene. Diseases associated with ELK1 include Non-Syndromic X-Linked Intellectual Disability and Autism …

Elk-1 plays an important role in the regulation of cellular proliferation and apoptosis, thymocyte development, glucose homeostasis and brain function. The biological function of Elk-1 relies …

Feb 7, 2010 · Transcription Factor Elk-1 is a protein that belongs to the AP-1 family of transcription factors. It forms a complex with the serum response factor (SRF) and binds to the …

Elk-1 is an ETS-like gene that codes for a DNA binding protein that is involved in transcriptional activation, proliferation, differentiation, an activator of MAP kinases and induces apoptosis …

Phosphorylation of the transcriptional activation domain (TAD) of Elk-1 by the protein kinase ERK at multiple sites potentiates recruitment of the Mediator transcriptional coactivator complex and …

May 5, 2019 · ELK-1 is a transcription factor involved in ERK-induced cellular proliferation. Here, we show that its transcriptional activity is modulated by ubiquitination at lysine 35 (K35). The …

Elk-1, a member of the ternary complex factor family of Ets domain proteins that bind serum response elements, is activated by phosphorylation in a cell-specific manner in response to …

Oct 19, 2022 · We established the transcriptional activator Elk-1 as the top regulator of RGC gene expression associated with axon outgrowth in both models. We demonstrate that Elk-1 is …

ELK1 was a negative prognosticator of DFS, independent of ELK3, ELK4, clinical T-stage, pathology T-stage, prognostic grade, lymph node status, age, and race. In this study, we …