The ternary complex factor (TCF) Elk-1 is a transcription factor that regulates immediate early gene (IEG) expression via the serum response element (SRE) DNA consensus site.

2024年12月24日 · ELK1 (ETS Transcription Factor ELK1) is a Protein Coding gene. Diseases associated with ELK1 include Non-Syndromic X-Linked Intellectual Disability and Autism Spectrum Disorder. Among its related pathways are Toll Like Receptor 7/8 (TLR7/8) Cascade and Prolactin Signaling.

Elk-1 plays an important role in the regulation of cellular proliferation and apoptosis, thymocyte development, glucose homeostasis and brain function. The biological function of Elk-1 relies essentially on the interaction with other proteins.

2010年2月7日 · Transcription Factor Elk-1 is a protein that belongs to the AP-1 family of transcription factors. It forms a complex with the serum response factor (SRF) and binds to the serum response element (SRE) in the c-Fos promoter, playing a role in gene expression regulation in the brain.

Elk-1 is an ETS-like gene that codes for a DNA binding protein that is involved in transcriptional activation, proliferation, differentiation, an activator of MAP kinases and induces apoptosis [Shao, et al., 1998; Rao, et al., 1989; Hipskind, et al., 1991; Rao, 1994].

Phosphorylation of the transcriptional activation domain (TAD) of Elk-1 by the protein kinase ERK at multiple sites potentiates recruitment of the Mediator transcriptional coactivator complex and transcriptional activation, but the roles of individual phosphorylation events remained unclear.

2019年5月5日 · ELK-1 is a transcription factor involved in ERK-induced cellular proliferation. Here, we show that its transcriptional activity is modulated by ubiquitination at lysine 35 (K35). The level of ubiquitinated ELK-1 rises in mitogen-deprived cells and falls upon mitogen stimulation or oncogene expression.

Elk-1, a member of the ternary complex factor family of Ets domain proteins that bind serum response elements, is activated by phosphorylation in a cell-specific manner in response to growth factors and other agents.

2022年10月19日 · We established the transcriptional activator Elk-1 as the top regulator of RGC gene expression associated with axon outgrowth in both models. We demonstrate that Elk-1 is necessary and...

ELK1 was a negative prognosticator of DFS, independent of ELK3, ELK4, clinical T-stage, pathology T-stage, prognostic grade, lymph node status, age, and race. In this study, we identified the main regulatory region of KATNA1 gene encoding katanin-p60 as 5' UTR, which has a key role for its expression, and showed Elk1 binding to KATNA1.