EGR-1 (Early growth response protein 1) or NGFI-A (nerve growth factor-induced protein A) is a protein that in humans is encoded by the EGR1 gene. EGR-1 is a mammalian transcription factor. It was also named Krox-24, TIS8, and ZENK. It was originally discovered in mice.

2024年12月24日 · EGR1 (Early Growth Response 1) is a Protein Coding gene. Diseases associated with EGR1 include Myelodysplastic Syndrome and Ischemia. Among its related pathways are PIP3 activates AKT signaling and Hepatocyte growth factor receptor signaling.

Egr-1(early growth responsive gene-1,Egr-1)是重要的核转录因子,其编码多种蛋白,在调控细胞的生长,分化,发育,增殖,炎性反应等方面发挥重要作用,本文针对其基因结构及特点,生物学特性,与肿瘤,炎症及肝损伤的关系作一简要综述.Egr-1基因及其蛋白的结构与特点Egr-1基因编码 ...

2023年11月17日 · EGR1 is essential for monopoiesis and binds enhancers that regulate monocytic developmental genes such as CSF1R. However, differentiating macrophages present a very different EGR1 binding pattern. We identify novel binding sites of EGR1 at a large set of inflammatory enhancers, even in the absence of its binding motif.

研究者使用Egr-1基因敲除小鼠（Egr-1−/−）来评估Egr-1对VEGFA、PDGFB和ANGPTL4生产的影响。 通过酶联免疫吸附试验（ELISA），研究者发现感染导致的VEGFA、PDGFB和ANGPTL4在 Egr-1−/− 小鼠脑中的上调明显低于野生型（WT）小鼠（Fig 7A）。

2021年11月10日 · Early growth response‐1 (Egr‐1) is a master regulator and transcriptional sensor in vascular dysfunction and disease. This article reviews recent developments in our understanding of the regulatory roles this zinc finger protein and product of an immediate‐early gene plays in a range of cardiovascular and inflammatory disorders.

Egr-1 is a key regulator of the blood-brain barrier damage induced by meningitic Escherichia coli. Early growth response 1 promoted the invasion of glioblastoma multiforme by elevating HMGB1.

2021年1月13日 · EGR1 is essential for monopoiesis and binds enhancers that regulate monocytic developmental genes such as CSF1R. However, differentiating macrophages present a very different EGR1 binding pattern. We identify novel binding sites of EGR1 at a large set of inflammatory enhancers, even in the absence of its binding motif.

2005年9月2日 · Egr1 is a novel and logical target for intervention by gene therapy methods, and targeting methods are discussed. Egr1 or the early growth response gene product is a zinc-finger transcription...

2021年3月24日 · Early growth response factor 1 (EGR1) is a transcription factor that is mainly involved in the processes of tissue injury, immune responses, and fibrosis. Recent studies have shown that EGR1 is closely related to the initiation and progression of cancer and may participate in tumor cell proliferatio …