The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is a transmembrane protein that is a receptor for members of the epidermal growth factor family (EGF family) of extracellular protein ligands.

2025年2月19日 · The epidermal growth factor receptor (EGFR) is a protein embedded in the outer membrane of epithelial and mesenchymal cells, bone cells, blood and immune cells, heart cells, glia and stem neural cells.

2006年9月25日 · The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase receptor that is frequently expressed in epithelial tumors. The EGFR was the first receptor to be proposed as a target for cancer therapy, and after 2 decades of intensive research, there are several anti-EGFR agents available in the clinic.

2024年12月24日 · EGFR is a cell surface protein that binds to epidermal growth factor, thus inducing receptor dimerization and tyrosine autophosphorylation leading to cell proliferation. Mutations in this gene are associated with lung cancer.

2006年12月15日 · The epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases, including EGFR, HER2/erbB2, and HER3/erbB3, is an attractive target for antitumor strategies.

A protein found on certain types of cells that binds to a substance called epidermal growth factor. The epidermal growth factor receptor protein is involved in cell signaling pathways that control cell division and survival.

The EGF receptor, shown here in blue, is a flexible protein with many moving parts, including a large extracellular portion, a section that crosses the cell membrane, a kinase domain and a long flexible tail.

4 天之前 · EGF/EGFR overview. EGFR(Epidermal growth factor receptor), or ErbB1/human epidermal growth factor receptor (HER)-1, is a transmembrane protein which is the receptor of the ligands from EGF family. EGFR is a 170-kDa glycoprotein with tyrosine kinase activity.

2022年7月6日 · MIT chemists discovered how the epidermal growth factor receptor changes its shape when it binds to its target, and how those changes trigger cells to grow and proliferate.

The epidermal growth factor receptor (EGFR) belongs to the ERBB family of tyrosine kinase receptors. EGFR signaling cascade is a key regulator in cell proliferation, differentiation, division, survival, and cancer development.