Epidermal growth factor (EGF) is a protein that stimulates cell growth and differentiation by binding to its receptor, EGFR. Human EGF is 6-kDa [5] and has 53 amino acid residues and three intramolecular disulfide bonds. [6] EGF was originally described as a secreted peptide found in the submaxillary glands of mice and in human urine.

Schematic representation of EGF gene, mRNA and protein. A) The EGF precursor gene has 110–130 kb pairs and 24 exons. Some exons encoded protein segments that are homologuous to sequences in other proteins, like LDL receptor, EGF-like repeats, and TGF-α …

2024年12月24日 · EGF (Epidermal Growth Factor) is a Protein Coding gene. Diseases associated with EGF include Hypomagnesemia 4, Renal and Egf-Related Primary Hypomagnesemia With Intellectual Disability. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and Signaling by EGFR in Cancer.

Know comprehensive EGF protein information including protein sequence, molecular weight, theoretical pI, structure, function and protein interaction.

Here, we review the molecular mechanisms that regulate EGFR signal transduction, including the EGFR structure and its mutations, ligand binding and EGFR dimerization, as well as the signaling pathways that lead to G1 cell cycle progression.

Epidermal growth factor (EGF) is a single polypeptide of 53 amino acid residues which is involved in the regulation of cell proliferation. Egf exerts its effects in the target cells by binding to the plasma membrane located EGF receptor. The EGF receptor is a …

Epidermal Growth Factor (EGF) is a protein that, when applied to a damaged peripheral nerve, enhances axon regeneration, promotes the development of larger diameter axons, and improves neurological recovery by inducing Schwann cell proliferation and the …

EGF is part of a family of proteins that controls aspects of cell growth and development. Epidermal growth factor (red) and its receptor (blue). The inactive form (left) dimerizes when it binds to the hormone (right). The cell membrane is shown schematically in gray.

EGF domains are modular protein subunits found singly or in tandem, mostly in the extracellular milieu, where they are involved in a diverse array of functions. Intercellular signaling mediated by EGF-containing ligands and their cognate receptors are important regulators of …

2025年2月8日 · The encoded preproprotein is proteolytically processed to generate the 53-amino acid epidermal growth factor peptide. This protein acts a potent mitogenic factor that plays an important role in the growth, proliferation and differentiation of numerous cell types.