ESR1 Gene - GeneCards | ESR1 Protein | ESR1 Antibody
2024年12月25日 · ESR1 (Estrogen Receptor 1) is a Protein Coding gene. Diseases associated with ESR1 include Estrogen Resistance and Breast Cancer. Among its related pathways are …
ESR1 Mutation: Impact on Hormone-Sensitive Disorders
1 天前 · Research into ESR1 mutations has expanded, shedding light on their impact on cellular signaling and therapeutic response. As detection methods improve, interest grows in their …
ESR1 Mutations in Breast Cancer - PMC - PubMed Central (PMC)
In this review, we discuss mechanisms of resistance and dissemination of ESR1 mutations, as well as detection methods for ESR1 mutation tracking, newly discovered potential therapeutic …
ESR1 estrogen receptor 1 [ Homo sapiens (human) ] - National …
2025年2月8日 · Estrogen receptor 1 chromatin profiling in human breast tumors reveals high inter-patient heterogeneity with enrichment of risk SNPs and enhancer activity at most …
Testing for ESR1 Mutations to Guide Therapy for Hormone …
2023年5月17日 · To aid in treatment selection, the Expert Panel recommends routine testing for emergence of ESR1 mutations at recurrence or progression on ET (given with or without …
ESR1 mutation as an emerging clinical biomarker in metastatic …
2021年8月15日 · In metastatic hormone receptor-positive breast cancer, ESR1 mutations are a common cause of acquired resistance to the backbone of therapy, estrogen deprivation by …
ESR1 activating mutations: From structure to clinical application
2023年1月1日 · Activating ESR1 ligand binding domain mutations engender constitutive/ligand independent transcriptional activities and emerge following prolonged first-line hormone …
ESR1 mutations in breast cancer - PubMed
2019年11月1日 · The acquisition of ligand-independent ESR1 mutations during aromatase inhibitor therapy in metastatic estrogen receptor (ER)-positive breast cancer is a common …
Genomic and clinical landscape of metastatic hormone receptors …
2024年10月1日 · Somatic genetic alterations of the estrogen receptor 1 gene (ESR1) are enriched in endocrine therapy-resistant, estrogen receptor-positive (ER+) metastatic breast cancer …
Testing for ESR1 Mutations to Guide Therapy for HR-Positive, …
2023年5月17日 · This update focuses on testing for ESR1 mutations in patients with hormone receptor-positive, HER2-negative metastatic breast cancer, and presents treatment …