Extracellular signal-regulated kinase 5 (ERK5), also termed big mitogen-activated protein kinase-1 (BMK1), is the most recently identified member of the mitogen-activated protein kinase (MAPK) family and consists of an amino-terminal kinase domain, with a …

Extracellular signal-regulated kinase 5 (ERK5) is a unique kinase among MAPKs family members, given its large structure characterized by the presence of a unique C-terminal domain.

Extracellular-signal-regulated kinase 5 (ERK5) is a member of the mitogen-activated protein kinase (MAPK) family and, similar to ERK1/2, has the Thr–Glu–Tyr (TEY) activation motif. Both ERK5 and ERK1/2 are activated by growth factors and have an ...

ERK5, the last MAP kinase family member discovered, is activated by the upstream kinase MEK5 in response to growth factors and stress stimulation. MEK5-ERK5 pathway has been associated to different cellular processes, playing a crucial role in cell ...

2020年6月23日 · ERK5, the least studied of the conventional MAPKs, is also activated by mitogens, growth factors and specific stress conditions such as oxidative and osmotic stresses.

2001年9月9日 · Extracellular signal regulated kinase 5 (ERK5) is a novel member of the mitogen-activated protein kinase (MAPK) family with a poorly defined physiological function. Since ERK5 and its upstream activator MEK5 are abundant in skeletal muscle we examined a function of the cascade during muscle differentiation.

2015年5月1日 · We reveal that ERK5 is an ischemic sensor in platelets, contributing to ongoing post-MI platelet activation that accelerates ventricular remodeling and systolic dysfunction. Our data also demonstrate that ERK5 regulates platelet protein expression post-MI.

2012年11月1日 · ERK5 is a relatively recently identified MAPK and has been associated with a diverse range of cellular processes including cellular proliferation, migration, survival and angiogenesis. This review focuses on ERK5 and recent progress in understanding its structure, regulation and function in mammals. 2. Discovery of ERK5.

We found that ERK5 and its direct downstream target transcription factor MEF2C are upregulated by 1,25D in parallel with monocytic differentiation.

2022年1月11日 · In this review, we explore the gene expression profile of ERK5 among cancers correlated with its clinical impact, as well as the prognostic value of ERK5 and pERK5 expression levels in tumors.

2021年5月12日 · In this study, we report that a high level of ERK5 is a predictive marker of metastatic breast cancer. Mechanistically, our in vitro data revealed that ERK5 was critical for maintaining the...

2021年7月15日 · The MEK5/ERK5 mitogen-activated protein kinases (MAPK) cascade is a unique signaling module activated by both mitogens and stress stimuli, including cytokines, fluid shear stress, high osmolarity, and oxidative stress.

We show that ERK5 drives lklf transcription by activating MEF2 transcription factors. Expression of erk5 short hairpin or a dominant-negative form of the ERK5 upstream activator, MEK5, in T cells led to downregulation of LKLF, increased cell size and upregulation of activation markers.

The MEK5/ERK5 mitogen-activated protein kinases (MAPK) cascade is a unique signaling module activated by both mitogens and stress stimuli, including cytokines, fluid shear stress, high osmolarity, and oxidative stress.

2025年2月25日 · The extracellular signal-related kinase 5 (ERK5), also referred to as big mitogen-activated kinase 1 (BMK1), belongs to the mitogen-activated protein kinase (MAPK) family [].ERK5 is involved in several biological responses, including cell survival, anti-apoptotic signaling, angiogenesis, differentiation and proliferation of several cell types [], and plays a relevant role …

2023年1月17日 · In this study, we demonstrated the role of the extracellular signal-regulated kinase 5 (ERK5)/mitogen-activated protein kinase in the regulation of YAP activity.

2021年7月15日 · The MEK5/ERK5 mitogen-activated protein kinases (MAPK) cascade is a unique signaling module activated by both mitogens and stress stimuli, including cytokines, fluid shear stress, high osmolarity, and oxidative stress.

Extracellular-signal-regulated kinase 5 (ERK5) is a member of the mitogen-activated protein kinase (MAPK) family and, similar to ERK1/2, has the Thr-Glu-Tyr (TEY) activation motif. Both ERK5 and ERK1/2 are activated by growth factors and have an important role in the regulation of cell proliferation …

2025年2月20日 · ERK1/2 inhibition induces compensatory ERK5 phosphorylation and promotes TNBC progression. ERK1/2 has become a key target for anticancer therapy, yet the compensatory mechanism between ERK1/2 and ...

2024年5月4日 · Recent studies have highlighted ERK5’s significant role in both bone development and bone-associated pathologies. This review offers a detailed examination of the latest research on ERK5 in different tissues and diseases, with a particular focus on its implications for bone health.

Extracellular signal-regulated kinase 5 (Erk5) belongs to the mitogen-activated protein kinase (MAPK) family and is specifically phosphorylated and subsequently activated by MAPK/Erk5 kinase 5 (Mek5) . Compared to classical MAPKs Erk1/2, Erk5 is unique in that it has distinctive structures on its C-terminus with two proline-rich domains and a ...

ERK5 modulates in vitro and in vivo growth of 3MC-C3 cell line. (A) 3MC-C3 cells were infected with lentiviruses carrying PLKO.1 empty vector (E.V.) or the PLKO.1-shRNA ERK5-1 vector (shERK5-1). Interference was evaluated by RT-qPCR using β-2-microglobulin (B2m) as an endogenous control (left panel). E.V. cells were considered as 1.

2025年2月28日 · Background Cellular senescence is a state of irreversible cell growth arrest. As such, senescence induction is viewed as an efficacious countermeasure in cancer treatment. Flap endonuclease 1 (FEN1) has been reported to participate in tumor growth, metastasis and immunomodulation. However, the role of FEN1 in cellular senescence of breast cancer and its …