2023年11月23日 · 癌症治疗领域： enpp1抑制剂 是一种针对癌症免疫治疗的新型药物，它的作用机制是通过阻断enpp1的活性，从而增强肿瘤细胞外的cgamp信号，激活邻近的免疫细胞，同 …

2024年12月24日 · ENPP1 (Ectonucleotide Pyrophosphatase/Phosphodiesterase 1) is a Protein Coding gene. Diseases associated with ENPP1 include Cole Disease and Hypophosphatemic …

ENPP1 has broad specificity and cleaves a variety of substrates, including phosphodiester bonds of nucleotides and nucleotide sugars. ENPP1 protein may function to hydrolyze nucleoside 5′ …

ENPP1, as a highly potent cGAMP-degradation enzyme, makes the application of ENPP1 inhibitors for anti-tumor therapy a very topical issue. For virally-infected hosts, small molecule …

enpp1抑制可增强对肿瘤免疫检查点抑制疗法的应答. 研究人员还对人类癌症样本中的enpp1进行了研究，他们发现enpp1的表达与转移增加和对 免疫疗法 的耐药有关。 enpp1的表达与人类癌 …

2019年11月19日 · This emerging role of ENPP1 has placed this "old" enzyme at the frontier of immunotherapy. This review highlights the roles played by ENPP1, the mechanism of cGAMP …

2023年9月22日 · enpp1是胞外环磷酸鸟苷-腺苷合成酶（cgamp）最主要的水解酶，可以将其水解为amp和gmp，从而提高胞外腺苷水平。 研究表明，腺苷水平过高会抑制免疫细胞的功能，而 …

ENPP1 is a genetic determinant of obesity-related phenotypes in a Mexican American population with type 2 diabetes mellitus. The prevalence of the PC-1 121Q allele was significantly higher …

The ENPP1 gene provides instructions for making a protein called ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1). The ENPP1 protein helps break down a …

Ecto-nucleotide pyrophosphatase/phosphodiesterase (ENPP) family members (ENPP1–7) have been implicated in key biological and pathophysiological processes, including nucleotide and …