Ubiquitin-protein ligase E3A (UBE3A) also known as E6AP ubiquitin-protein ligase (E6AP) is an enzyme that in humans is encoded by the UBE3A gene. This enzyme is involved in targeting …

E6-AP 是一种 HECT 结构域 E3 泛素连接酶，会与丙型肝炎病毒 (HCV) 核心蛋白相互作用，并靶向这种蛋白进行降解。 HCV 核心蛋白对包装病毒 DNA 和其他细胞进程非常重要。 E6-AP 还 …

The ubiquitin ligase E6-AP (E6-associated protein) represents a prime example for the notion that deregulated modification of proteins with ubiquitin contributes to the development of human …

2024年4月26日 · Here we show that E6AP and the E6AP/E6 complex exist, respectively, as a monomer and a dimer of the E6AP/E6 protomer. The short α1-helix of E6AP transforms into a …

E6-AP is a hect (homologous to E6-associated protein carboxy-terminal domain) domain containing E3 ubiquitin ligase that possesses two independent separable functions; a …

2018年10月25日 · Deregulation of the ubiquitin ligase E6AP is causally linked to the development of human disease, including cervical cancer. In complex with the E6 oncoprotein of human …

2020年3月10日 · Regulated proteolysis by proteasomes involves ~800 enzymes for substrate modification with ubiquitin, including ~600 E3 ligases. We report here that E6AP/UBE3A is …

2024年5月15日 · 该研究利用冷冻电镜技术分别解析了E6AP和E6结合E6AP不同构象复合物结构，并结合分子动力学模拟分析和生化实验，系统揭示了E6AP活性动态调控的分子机制。 …

2013年10月5日 · In this review, we delineate genetic and biochemical knowledge of E6AP and we focus on its role in the pathobiology of neuro-developmental and neuro-aging diseases; …

The E6-associated protein (E6-AP), although originally identified as a ubiquitin ligase, has recently been shown to function as a coactivator of steroid receptor-dependent gene expression in in …