2024年12月24日 · E2F4 (E2F Transcription Factor 4) is a Protein Coding gene. Diseases associated with E2F4 include Colorectal Cancer and Retinoblastoma. Among its related …

Here we review the canonical functions of E2F4 and discuss recent evidence expanding the role of this transcription factor, with a focus on cell fate decisions in tissue homeostasis and …

E2F4, PHACTR3, PRAME family member and CDH12 most probably play important role in non-small-cell lung cancer geneses; E2F4 may be determinant in the promotion of proliferation of …

2019年7月3日 · Here we show that E2F4 is important for the proliferation and the survival of mouse embryonic stem cells. In these cells, E2F4 acts in part as a transcriptional activator that …

2019年5月3日 · In this Review, we discuss the activities of E2F proteins with an emphasis on the newest atypical E2F family members, the specific and redundant functions of E2F proteins, …

We used ChIP sequencing (ChIP-seq) to identify around 16 000 E2F4 binding sites which potentially regulate 7346 downstream target genes with wide-ranging functions in DNA repair, …

2023年8月23日 · Replicative stress blunts Trim33-dependent ubiquitination of E2f4, which stimulates transient Recql recruitment to chromatin and facilitates recovery of DNA synthesis.

2024年1月26日 · E2F4 transcription factor is a prognostic biomarker related to immune infiltration of head and neck squamous cell carcinoma. Qi L, et al. Sci Rep, 2022 Jul 15. PMID …

E2F4 binds p130 and localizes to the nucleus following PC12 cell differentiation. E2F4 interactions with Rb family proteins have a major impact on E2F4 function, including its …

We show that E2F4 is fully dispensable for the control of cellular proliferation but it plays a critical role in terminal differentiation. In particular, E2F4 is essential for end stage maturation of …