Dec 24, 2024 · E2F1 (E2F Transcription Factor 1) is a Protein Coding gene. Diseases associated with E2F1 include Retinoblastoma and Squamous Cell Carcinoma. Among its related pathways are Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects and Mitotic G1 phase and G1/S transition.

E2F proteins regulate the transcription of S phase cyclins and genes required for DNA replication, DNA repair, and apoptosis. The activity of E2F1, the archetypal and most heavily studied E2F family member, is tightly controlled by the DNA damage checkpoints to modulate cell cycle progression and initiate programmed cell death, when required.

E2F1 shows structural homology with other E2F activators. It has a single DNA binding domain and heterodimerizes with a dimerization partner (DP1/DP2) in order to effectively bind DNA and recruit other transcription factors and co-activators to target gene promoters.

May 3, 2019 · This study shows that minor copy number changes (one to two extra copies) of E2f1 or E2f3b are sufficient to induce liver cancer in mice.

Nov 10, 2017 · We summarize recent findings about the cell cycle-independent roles of E2F1 in various tissues that contribute to global metabolic homeostasis and highlight that E2F1 activity is increased during obesity.

Sep 18, 2019 · In this study, we show that E2F1 regulates gene expression for HR factors and DNA replication. We also demonstrate an essential role for the HR pathway in colon cancer progression.

E2F1 has a cancer protective role in oncogenic BRAF-activated melanoma cells. E2F1 promotes the transcription of lncRNA RGMB-AS1 in papillary thyroid carcinoma (PTC). blocking E2F1 also induced death of melanoma cells resistant to BRAF inhibitors.

Using a conditional gene-targeting approach, we show that the targeted disruption of the entire E2F activator subclass composed of E2f1, E2f2, and E2f3 in mouse embryonic fibroblasts leads to the activation of p53 and the induction of p53 target genes, including p21CIP1.

Feb 9, 2025 · In cultured neurons, HIV-1 gp120 increases transcription factor E2F1 levels in the nucleus, stimulates its transcriptional activity, and enhances the expression of the E2F1 target proteins Cdc2 and Puma

Oct 11, 2022 · E2F1 drives the cell cycle of CRC by promoting spindle assembly, in which E2F1-induced stathmin1 and TACC3 enhance the stability of spindle fiber.