Segment polarity protein dishevelled homolog DVL-2 is a protein that in humans is encoded by the DVL2 gene. [5] [6] This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid …

2024年12月24日 · DVL2 (Dishevelled Segment Polarity Protein 2) is a Protein Coding gene. Diseases associated with DVL2 include Acyl-Coa Dehydrogenase, Very Long-Chain, Deficiency Of and Robinow Syndrome. Among its related pathways are ncRNAs involved in Wnt signaling in hepatocellular carcinoma and Autodegradation of the E3 ubiquitin ligase COP1.

Disheveled (Dsh) 蛋白（Dvl1、Dvl2 和 Dvl3）抑制糖原合成酶激酶-3β，从而增强 β-连环蛋白的稳定性 。Naked 可通过结合 Dsh 蛋白 并调控平面细胞极性通路的 Dsh 活性，从而抑制典型 Wnt/β-连环蛋白通路 。 配体：wnt1，wnt2，wnt3，wnt3a. 受体：LRP5/6，Frizzled家族蛋白. Dvl ...

2020年7月6日 · Dishevelled-2 (DVL2) is a central adaptor protein that propagates signals from upstream receptors to downstream effector β-catenin in canonical Wnt signaling.

散乱片段极性蛋白 2： 该基因编码蓬乱 (dsh) 蛋白家族的一个成员。脊椎动物 dsh 蛋白与果蝇 dsh 的氨基酸序列相似性约为 40%。该基因编码一个 90-kD 的蛋白，该蛋白经过翻译后磷酸化形成一个 95-kD 的胞质蛋白，可能在多种 Wnt 蛋白介导的信号转导通路中发挥作用。 Wnt 信号传导中功能紊乱的机制可能在 ...

Dvl2 could play a part in epithelial ovarian cancer progression and might be an independent prognostic factor. Additionally, it might be a prospective therapeutic target in the treatment of EOC. Our findings reveal an underappreciated role of Dvl2 in regulating inflammation and rheumatoid arthritis-fibroblast-like synoviocyte apoptosis

2022年12月15日 · Dishvelled-2 (Dvl2) is an essential component of Wnt pathway, which controls several cell fate decisions during development, such as proliferation, survival and differentiation. Dvl2 forms higher-order protein assemblies in the cell that are critical for relaying the signal from upstream Wnt ligand- …

2025年2月20日 · Title: Dvl2 facilitates the coordination of NF-κB and Wnt signaling to promote colitis-associated colorectal progression. Targeting E3 Ubiquitin Ligase WWP1 Prevents Cardiac Hypertrophy Through Destabilizing DVL2 via Inhibition of K27-Linked Ubiquitination.

Dishevelled (Dvl) is a central node of Wnt signaling. Insulin receptor substrates (IRSs), as critical component of insulin signaling, are involved in cell proliferation, metabolism and cancer development. In this study, we report that IRS1/2 promotes Wnt/β-catenin signaling by stabilizing Dvl2. We found that IRS1/2 interacts with Dvl2……

2025年2月8日 · Dvl2 mediates a conserved mammalian PCP pathway to regulate convergent extension during neurulation. has a predominant role in mediating Wnt-3a-dependent cell motility; The direct interaction of Dvl2 with AP-2 is important for Frizzled internalization and Frizzled/planar cell polarity signaling.