Drosha is a Class 2 ribonuclease III enzyme [5] that in humans is encoded by the DROSHA (formerly RNASEN) gene. [6][7][8] It is the primary nuclease that executes the initiation step of …

2024年12月24日 · DROSHA (Drosha Ribonuclease III) is a Protein Coding gene. Diseases associated with DROSHA include Hereditary Breast Ovarian Cancer Syndrome and Lynch …

Drosha is the catalytic center of the microprocessor and has two RNase-III domains that make up a catalytic site with each domain making one of the two cuts necessary to excise the pre …

2016年4月29日 · A recent study by Kwon et al. in Cell reveals the structure of a DROSHA construct in complex with the C-terminal region of DGCR8, thereby unveiling the topology and …

2016年1月14日 · The heretofore-elusive structure of DROSHA provides insights into how nascent microRNAs are recognized and cleaved in their initial processing step and reveals an …

2012年7月20日 · DROSHA is a nuclear RNase III enzyme responsible for cleaving primary microRNAs (miRNAs) into precursor miRNAs and thus is essential for the biogenesis of …

2016年1月14日 · MicroRNA maturation is initiated by RNase III DROSHA that cleaves the stem loop of primary microRNA. DROSHA functions together with its cofactor DGCR8 in a …

2018年2月7日 · Depletion of Drosha significantly reduces DNA repair by both homologous recombination (HR) and non-homologous end joining (NHEJ). Drosha is required within …

2024年7月30日 · Drosha, a key player in gene regulation, is an endoribonuclease enzyme responsible for initiating the processing of primary microRNA transcripts (pri-miRNAs) into …

2013年12月26日 · Drosha is the main RNase III-like enzyme involved in the process of microRNA (miRNA) biogenesis in the nucleus. Using whole-genome ChIP-on-chip analysis, we …