2024年12月24日 · DRAM1 (DNA Damage Regulated Autophagy Modulator 1) is a Protein Coding gene. Diseases associated with DRAM1 include Cone-Rod Dystrophy 21 and Achromatopsia 3. Among its related pathways is p53 transcriptional gene network. An important paralog of …

该基因作为 p53 肿瘤抑制通路的一部分进行调节。 该基因编码一种溶酶体膜蛋白，该蛋白是该途径诱导自噬所必需的。 该基因转录表达降低与多种肿瘤有关。 该基因在 4 号染色体上有一个假基因。 [RefSeq 提供，2008 年 7 月] This gene is regulated as part of the p53 tumor suppressor pathway. The gene encodes a lysosomal membrane protein that is required for the induction of Autophagy by the pathway.

2019年3月22日 · DRAM1 was localized at the plasma membrane and regulate the phosphorylation of IGF-1 receptor. DRAM1 decreased cell viability and colony numbers upon serum starvation. Additionally, DRAM1 inhibited rpS6 phosphorylation in several human cancer cells. Here we provided evidence that DRAM1 inhibited rpS6 phosphorylation in …

2025年2月8日 · DNA Damage-Regulated Autophagy Modulator 1 (DRAM1) Mediates Autophagy and Apoptosis of Intestinal Epithelial Cells in Inflammatory Bowel Disease. DRAM1 plays a tumor suppressor role in NSCLC cells by promoting lysosomal degradation of EGFR. DRAM1 deficiency affects the organization and function of the Golgi apparatus.

2025年1月4日 · Title: DNA Damage-Regulated Autophagy Modulator 1 (DRAM1) Mediates Autophagy and Apoptosis of Intestinal Epithelial Cells in Inflammatory Bowel Disease. DRAM1 plays a tumor suppressor role in NSCLC cells by promoting lysosomal degradation of EGFR.

2015年1月29日 · DRAM1 (DNA damage-regulated autophagy modulator 1) is a TP53 target gene that modulates autophagy and apoptosis. We previously found that DRAM1 increased autophagy flux by promoting lysosomal...

2024年9月18日 · It is well established that DNA Damage Regulated Autophagy Modulator 1 (DRAM1), a lysosomal protein and a target of p53, participates in autophagy. The cellular functions of DRAM1 beyond autophagy remain elusive. Here, we show p53-dependent upregulation of DRAM1 in mitochondrial damage-induced Parki …

本论文研究DRAM1调节细胞线粒体失能引起的自噬激活和细胞死亡的分子机制。 方法: (1)建立3-NP所致A549细胞线粒体失能毒性模型。3-NP处理细胞24, 48和72h后,Western blot法测定DRAM1,BAX,p62和LC3等凋亡和自噬蛋白的表达和线粒体细胞色素C的释放,免疫荧光法检测LC3的表达,观察自噬和凋亡通路的激活。 (2)观察自噬和凋亡过程在3-NP所致的细胞线粒体毒性引起的细胞死亡中的作用。 Western blot法检测Atg5的siRNA干扰效果。 WST-1法检测Atg5 siRNA干 …

2024年3月1日 · DRAM1 plays a tumor suppressor role in clear cell renal cell carcinoma through modulating Akt signaling. DRAM1 deficiency affects the organization and function of the Golgi apparatus. DRAM1 regulates autophagy and cell proliferation via inhibition of the phosphoinositide 3-kinase-Akt-mTOR-ribosomal protein S6 pathway.

2025年1月28日 · DNA damage-regulated autophagy modulator 1 (DRAM1) encodes a hexameric transmembrane protein that is predominantly located in lysosomes and induces autophagy;...