Dorsomorphin (DM) induces cardiomyogenesis in mouse ES cells. (A) DM-treated ES cells formed large areas of beating cardiomyocytes that expressed DsRed-Nuc under the cardiac α-MHC promoter (right), but DMSO-treated cells did not (left).

Dorsomorphin is a selective inhibitor of Bone morphogenetic protein (BMP) signaling. It has been found to inhibit BMP signals required for embryogenesis and promoted significant neural differentiation from human pluripotent stem cell (hPSC) lines.

2024年6月20日 · Here, we show that pharmacologically induced in vitro activation (by metformin) or inhibition (by dorsomorphin) of the AMPK pathway inhibits or promotes activation of ovarian primordial follicles...

The only reagent called dorsomorphin or compound C that is occasionally used as an AMPK inhibitor unfortunately inhibits several other kinases much more potently than AMPK and is therefore highly non-specific. In this chapter, we discuss the pros and cons of using this reagent to study AMPK functions.

Dorsomorphin inhibits the bone morphogenetic protein (BMP) pathway by targeting the type I BMP receptors activin receptor-like kinase (ALK) 2, ALK3, and ALK6.

We describe the use of dorsomorphin, a selective small molecule inhibitor of BMP signaling, to induce myocardial differentiation in mouse ES cells. Cardiac induction is very robust, increasing the yield of spontaneously beating cardiomyocytes by at least 20 fold.

2010年9月15日 · Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism.

Dorsomorphin is a low molecular weight inhibitor of BMPs including BMP 6 and its application induced hyperferremia due to hepcidin suppression in mice [116].

Dorsomorphin (Compound C) is a potent and reversible AMP-activated protein kinase (AMPK) inhibitor that competes with ATP in the absence of AMP with a K i value of 109 nM (1). This small compound is selective, displaying no significant inhibition of other kinases inclusive of ZAPK, SYK, PKCθ, PKA, and JAK3 (1).

Dorsomorphin is a small molecule inhibitor of bone morphogenetic protein (BMP) signaling, which plays crucial roles in both development and adult diseases like fibrodysplasia ossificans progressiva (FOP) and anemia of inflammation (AI).