2014年8月12日 · What is distal tubular renal acidosis (dRTA)? dRTA is a rare but serious type of kidney disease that can be inherited (primary dRTA) or be caused by another disorder or medication (secondary dRTA). Primary dRTA is also known as primary type 1 RTA.

2023年9月20日 · Distal (type 1) and proximal (type 2) renal tubular acidosis (RTA) are uncommon disorders, particularly in adults. Proximal RTA is characterized by a reduction in proximal bicarbonate reabsorptive capacity that leads to bicarbonate wasting in the urine until the serum bicarbonate concentration has fallen to a level low enough to allow all of ...

Distal renal tubular acidosis (dRTA) is the classical form of RTA, being the first described. Distal RTA is characterized by a failure of acid secretion by the alpha intercalated cells of the distal tubule and cortical collecting duct of the distal nephron. [1] This failure of acid secretion may be due to a number of causes.

Distal RTA (dRTA), also called type 1 RTA, is a rare genetic disorder characterized by the inability of the distal nephron to maximally increase the urinary secretion of protons (H +) in the presence of metabolic acidosis.

2023年7月17日 · Incomplete distal RTA: Patients with the incomplete form of distal RTA have a persistently high urine pH and hypocitraturia, as in the complete form, but can maintain net acid excretion and the plasma bicarbonate concentration in the normal range.

2019年10月10日 · Individuals with hereditary distal renal tubular acidosis (dRTA) typically present in infancy with failure to thrive, although later presentations can occur, especially in individuals with autosomal dominant SLC4A1-dRTA. Initial clinical manifestations can also include emesis, polyuria, polydipsia, constipation, diarrhea, decreased appetite ...

Distal renal tubular acidosis (dRTA) is characterized by an impairment of normal urinary acidification process in the distal part of the nephron in the presence of a normal glomerular filtration rate.

2023年4月4日 · Impaired acid excretion by the collecting duct system causes distal renal tubular acidosis (dRTA), which is characterized by the failure to acidify urine below pH 5.5. This defect...

Distal renal tubular acidosis (type I RTA) is caused by a defect in the kidney tubes that causes acid to build up in the blood. Type I RTA is caused by a variety of conditions, including: Amyloidosis, a buildup of abnormal protein, called amyloid, in the tissues and organs

2025年1月24日 · An entity termed “incomplete distal RTA” has been described in patients with high urine pH and recurrent calcium phosphate stone formation. These patients do not have NAGMA, and typically have preserved ammonium excretion, 2 features that are contrary to the diagnosis of true distal RTA.