Dicer - Wikipedia
Dicer, also known as endoribonuclease Dicer or helicase with RNase motif, is an enzyme that in humans is encoded by the DICER1 gene. Being part of the RNase III family, Dicer cleaves …
DICER: structure, function, and regulation - PMC - PubMed …
DICER is a multidomain endonuclease that belongs to the fourth class of type III ribonuclease (RNase III) enzymes. DICER is encoded by a single gene in vertebrates and C. elegans, …
Molecular mechanisms of Dicer: endonuclease and enzymatic …
The enzyme Dicer is best known for its role as a riboendonuclease in the small RNA pathway. In this canonical role, Dicer is a critical regulator of the biogenesis of microRNA and small …
Structure of the human DICER–pre-miRNA complex in a dicing state
Feb 22, 2023 · Human DICER (hDICER, also known as DICER1) is specialized for cleaving small hairpin structures such as precursor microRNAs (pre-miRNAs) and has limited activity towards …
DICER1 Tumor Predisposition - GeneReviews® - NCBI Bookshelf
Apr 24, 2014 · DICER1 tumor predisposition (DICER1) is characterized by an increased risk for pleuropulmonary blastoma (PPB), pulmonary cysts, thyroid gland neoplasia (multinodular …
DICER: structure, function, and regulation - PubMed
Nov 16, 2021 · In this review, we will summarize the structural features of DICER, describe its canonical and non-canonical roles, and discuss the most common regulatory mechanisms …
What is the DICER1 gene? - Cancer
What is the DICER1 gene? Everyone inherits two copies of the DICER1 gene from their parents, one from their mother and one from their father. This gene works to manage the function of …
Sequence determinant of small RNA production by DICER
Feb 22, 2023 · Dicer, a multidomain ribonuclease (RNase) III, serves as a key player in RNA silencing by cleaving double-stranded RNA (dsRNA) into small RNAs of 21–25 nucleotides (nt) …
DICER: structure, function, and regulation | Biophysical Reviews
Nov 16, 2021 · In this review, we will summarize the structural features of DICER, describe its canonical and non-canonical roles, and discuss the most common regulatory mechanisms …
Determinants of selectivity in the dicing mechanism
Oct 18, 2024 · DICER is a vital enzyme in small RNA production. Here the authors show how bipartite pairing rules and dual YCR motifs guide DICER's activity on precursor microRNAs.