Dicer, also known as endoribonuclease Dicer or helicase with RNase motif, is an enzyme that in humans is encoded by the DICER1 gene. Being part of the RNase III family, Dicer cleaves double-stranded RNA (dsRNA) and pre-microRNA (pre-miRNA) into short double-stranded RNA fragments called small interfering RNA and microRNA , respectively.

What is the DICER1 gene? Everyone inherits two copies of the DICER1 gene from their parents, one from their mother and one from their father. This gene works to manage the function of other genes. In most people, this gene works properly.

DICER is a multidomain endonuclease that belongs to the fourth class of type III ribonuclease (RNase III) enzymes. DICER is encoded by a single gene in vertebrates and C. elegans, although it can be present in more paralogs in other species.

2023年2月22日 · Human DICER (hDICER, also known as DICER1) is specialized for cleaving small hairpin structures such as precursor microRNAs (pre-miRNAs) and has limited activity towards long dsRNAs—unlike its...

Dicer, an RNase III enzyme, initiates the RNAi pathway, plays a pivotal role in fighting infection against pathogens, and acts as a housekeeping enzyme for cellular homeostasis. Here, we review structure-based functional insights of Dicer and its domains present in a …

The enzyme Dicer is best known for its role as a riboendonuclease in the small RNA pathway. In this canonical role, Dicer is a critical regulator of the biogenesis of microRNA and small interfering RNA, as well as a growing number of additional ...

Dicer is one of the key enzymes to process pre-miRNAs into mature miRNAs during miRNA biogenesis. In a retina-specific Dicer conditional knockout (ko) model, Chx10-cre, Dicerflox, Damiani et al. reported that levels of mature miRNAs were decreased in the ko retinas.

2021年11月16日 · In this review, we will summarize the structural features of DICER, describe its canonical and non-canonical roles, and discuss the most common regulatory mechanisms having an impact on DICER abundance and function.

2021年11月16日 · In this review, we will summarize the structural features of DICER, describe its canonical and non-canonical roles, and discuss the most common regulatory mechanisms having an impact on DICER abundance and function.

DICER is a multidomain endonuclease that belongs to the fourth class of type III ribonuclease (RNase III) enzymes. DICER is encoded by a single gene in vertebrates and C. elegans, although it can be present in more paralogs in other species.