Amiodarone is a class III antiarrhythmic drug and acts on the potassium channels resulting in prolongation of the action potential and repolarization. It has a very long half-life of 1–3 months …

Desethylamiodarone | C23H25I2NO3 | CID 104774 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, …

Desethylamiodarone (DEA) (Fig 1), the major metabolite of the widely used antiarrhythmic drug amiodarone, is produced in an N-demethylation reaction catalyzed by cytochrome P450 3A4 …

1985年11月1日 · The pharmacokinetic characteristics of amiodarone suggest extensive tissue deposition. We confirmed this by measuring tissue concentrations of the drug and of its major …

Aims: To predict the drug interactions of amiodarone and other drugs, the inhibitory effects and inactivation potential for human cytochrome P450 (CYP) enzymes by amiodarone and its N …

Only 60% of patients reached supposed minimally therapeutic effective levels of AM or DEA, 36% of them was underdosed and 4% of patients was likely non-compliant. Therefore routine TDM …

Previously, we demonstrated the in vitro anti-tumor effects of desethylamiodarone (DEA) in bladder and cervix cancer cell lines. In the present study, we intended to establish its …