Decorin is an extracellular matrix protein that belongs to the family of small leucine-rich proteoglycans. As a matrix protein, the first discovered role of decorin is participating in …

Decorin functions as a guardian in the context of constraining the activity of multiple growth factors, receptor tyrosine kinases, and extracellular matrix components. The source of decorin …

Decorin embraces a variety of binding partners branding it as a multi-purpose small, leucine-rich proteoglycan. Structural integrity and cellular signaling are two prominent themes found in the …

Decorin (DCN) is the best characterized member of the extracellular small leucine-rich proteoglycan family present in connective tissues, typically in association with or "decorating" …

Decorin is an important component of the cellular microenvironment or extracellular matrix (ECM). Its interactions with matrix and cell membrane components have been implicated in many …

Decorin is a member of the extracellular matrix small leucine-rich proteoglycans family that exists and functions in stromal and epithelial cells. Accumulating evidence suggests that decorin …

Decorin, an archetypal member of the small leucine-rich proteoglycan gene family, has a broad binding repertoire that encompasses matrix structural components, such as collagens, and …

Decorin also interacts with TGF-β isoforms. The core protein binds to TGF-β1 with high affinity. The addition of decorin to TGF-β1 enhances the inhibitory effect of the growth factor on …

Dec 21, 2018 · Decorin is a naturally occurring, pleiotropic, small leucine-rich proteoglycan that is naturally present at high levels bound to collagen in the corneal stroma and which, when …

Decorin is involved in the regulation of collagen fibrillogenesis and the decorin-deficient mouse has fragile skin and dysregulation of lateral fibril growth. This regulatory role is largely …