Decorin - Wikipedia
Decorin is a protein that in humans is encoded by the DCN gene. Decorin is a proteoglycan that is on average 90 - 140 kilodaltons (kDa) in molecular weight. It belongs to the small leucine-rich proteoglycan (SLRP) family and consists of a protein core containing leucine repeats with a glycosaminoglycan (GAG) chain consisting of either ...
DCN gene: MedlinePlus Genetics
The DCN gene provides instructions for making a protein called decorin. Learn about this gene and related health conditions.
Decorin Tablet - Uses, Side Effects, and More - WebMD
Pseudoephedrine is used for the temporary relief of stuffy nose and sinus pain/pressure caused by infection (such as the common cold, flu) or other breathing illnesses (such as hay fever,...
Decorin is a pivotal effector in the extracellular matrix and tumour ...
2018年1月3日 · Decorin (DCN), an extracellular matrix (ECM) protein, belongs to the small leucine-rich proteoglycan family. As a pluripotent molecule, DCN regulates the bioactivities of cell growth factors and participates in ECM assembly.
Decorin (DCN) is the best characterized member of the extracellular small leucine-rich proteoglycan family present in connective tissues, typically in association with or “decorating” collagen fibrils. It has substantial interest to clinical medicine owing to its antifibrotic, anti-inflammatory, and anticancer efects.
Role of Decorin in the Lens and Ocular Diseases - MDPI
Decorin is an archetypal member of the small leucine-rich proteoglycan gene family and is involved in various biological functions and many signaling networks, interacting with extra-cellular matrix (ECM) components, growth factors, and receptor tyrosine kinases.
Decorin Biology, Expression, Function and Therapy in the Cornea
Decorin is a small leucine-rich proteoglycan (SLRP) that plays a vital role in many important cellular processes in several tissues including the cornea. A normal constituent of the corneal stroma, decorin is also found in the majority of connective tissues and is related structurally to other small proteoglycans.
The Role of Decorin Proteoglycan in Mitophagy - MDPI
2022年2月4日 · Decorin is a prime mechanistic example of how PGs can elicit dramatic responses within cells via RTK signaling. Decorin is the archetypical member of the small leucine rich proteoglycan (SLRP) gene family and harbors a single covalently attached dermatan/chondroitin sulfate chain at its N-terminus.
The small proteoglycan decorin supports adhesion and …
2002年9月1日 · Decorin is a small leucine-rich proteoglycan able to interact with several molecules of the subendothelial matrix, such as collagen and fibronectin. In this work, we investigated the ability of purified decorin to support adhesion of human platelets. We found that gel-filtered platelets were actually able to interact with immobilized decorin.
The Role of Decorin in Cancer - SpringerLink
2022年7月7日 · Decorin is capable to modulate the effects of certain therapeutic drugs. Decorin exerts a synergistic effect with carboplatin by hindering the proliferation of ovarian cancer cells (Nash et al. 1999).
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