Decitabine is a hypomethylating agent. [7] [8] It hypomethylates DNA by inhibiting DNA methyltransferase. It functions in a similar manner to azacitidine, although decitabine can only …

Decitabine is a chemotherapeutic pyrimidine nucleoside analogue used for the treatment of myelodysplastic syndromes (MDS) by inducing DNA hypomethylation and corresponding …

The ceRNA mechanism is used in the pathogenesis, diagnosis, treatment, and prognostic prediction of most tumors, including AML. miRNAs can exert powerful regulatory functions in a …

Dual modes of action of decitabine. The antineoplastic action of decitabine results from its incorporation into newly synthesized DNA. It is an S-phase-specific agent 11 and has a dual, …

Decitabine is believed to have a dual mechanism of action depending on dose. At both lower and higher doses, decitabine incorporates into DNA; however, at higher doses, decitabine inhibits …

14 Mechanism of Action 15 Decitabine is believed to exert its antineoplastic effects after phosphorylation and direct incorporation 16 into DNA and inhibition of DNA methyltransferase,...

Sep 26, 2023 · Decitabine (DAC) is clinically used to treat myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). Our genome-wide CRISPR-dCas9 activation screen using …

Jul 1, 2008 · To maximize the clinical efficacy of azacytidine and decitabine it will be important to understand the molecular changes induced by these drugs. In this review, we examine the …

Feb 17, 2020 · Mechanism of Action. Decitabine is a hypomethylating agent. After phosphorylation, decitabine is incorporated into DNA and inhibits DNA methyltransferase …

Chemistry and Mechanism of Action: Decitabine is a synthetic nucleoside analog of 2′-deoxycytidine, a cytotoxic S-phase pyrimidine analogue that induces hypomethylation of DNA …